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Showing results for brain kittler
Search for Brian Kittler instead (1 results)
Elimination of Radiation-Induced Senescence in the Brain Tumor Microenvironment Attenuates Glioblastoma Recurrence.
Fletcher-Sananikone E, Kanji S, Tomimatsu N, Di Cristofaro LFM, Kollipara RK, Saha D, Floyd JR, Sung P, Hromas R, Burns TC, Kittler R, Habib AA, Mukherjee B, Burma S. Fletcher-Sananikone E, et al. Cancer Res. 2021 Dec 1;81(23):5935-5947. doi: 10.1158/0008-5472.CAN-21-0752. Epub 2021 Sep 27. Cancer Res. 2021. PMID: 34580063 Free PMC article.
Here, we carried out transcriptomic and tumorigenicity analyses in irradiated mouse brains to elucidate how radiotherapy-induced senescence of non-neoplastic brain cells promotes tumor growth. ...Preirradiation of mouse brains increased Met-driven growth and …
Here, we carried out transcriptomic and tumorigenicity analyses in irradiated mouse brains to elucidate how radiotherapy-induced sene …
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction.
Hirunpattarasilp C, James G, Kwanthongdee J, Freitas F, Huo J, Sethi H, Kittler JT, Owens RJ, McCoy LE, Attwell D. Hirunpattarasilp C, et al. Brain. 2023 Feb 13;146(2):727-738. doi: 10.1093/brain/awac272. Brain. 2023. PMID: 35867861 Free PMC article.
A similar RBD-potentiated capillary constriction occurred in human cortical slices, and was evoked in hamster brain slices by pseudotyped virions expressing SARS-CoV-2 spike protein. ...Thus, AT1 receptor blockers could be protective in COVID-19 by preventing pericyte-medi …
A similar RBD-potentiated capillary constriction occurred in human cortical slices, and was evoked in hamster brain slices by pseudot …
Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis.
Ferreira APA, Casamento A, Carrillo Roas S, Halff EF, Panambalana J, Subramaniam S, Schützenhofer K, Chan Wah Hak L, McGourty K, Thalassinos K, Kittler JT, Martinvalet D, Boucrot E. Ferreira APA, et al. Nat Commun. 2021 Apr 23;12(1):2424. doi: 10.1038/s41467-021-22603-4. Nat Commun. 2021. PMID: 33893293 Free PMC article.
Mitochondrial regulation of local supply of energy in neurons.
López-Doménech G, Kittler JT. López-Doménech G, et al. Curr Opin Neurobiol. 2023 Aug;81:102747. doi: 10.1016/j.conb.2023.102747. Epub 2023 Jun 29. Curr Opin Neurobiol. 2023. PMID: 37392672 Free article. Review.
Brain computation is metabolically expensive and requires the supply of significant amounts of energy. ...Neurons coordinate these processes through signalling pathways that couple energetic expenditure with energy availability. When these mechanisms fail, neurons can no l …
Brain computation is metabolically expensive and requires the supply of significant amounts of energy. ...Neurons coordinate these pr …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
ALK Amplification and Rearrangements Are Recurrent Targetable Events in Congenital and Adult Glioblastoma.
Blandin AF, Giglio R, Graham MS, Garcia G, Malinowski S, Woods JK, Ramkissoon S, Ramkissoon L, Dubois F, Schoolcraft K, Tsai J, Wang D, Jones R, Vogelzang J, Pelton K, Becker S, Watkinson F, Sinai C, Cohen EF, Booker MA, Tolstorukov MY, Haemels V, Goumnerova L, Wright K, Kieran M, Fehnel K, Reardon D, Tauziede-Espariat A, Lulla R, Carcamo B, Chaleff S, Charest A, De Smet F, Ligon AH, Dubuc A, Pages M, Varlet P, Wen PY, Alexander BM, Chi S, Alexandrescu S, Kittler R, Bachoo R, Bandopadhayay P, Beroukhim R, Ligon KL. Blandin AF, et al. Clin Cancer Res. 2023 Jul 14;29(14):2651-2667. doi: 10.1158/1078-0432.CCR-21-3521. Clin Cancer Res. 2023. PMID: 36780194 Free PMC article.
Relevant to the treatment of infant gliomas, we showed that ALK protein appears minimally expressed in the forebrain at perinatal stages, and no gross effects on perinatal brain development were seen in pregnant mice treated with the ALK inhibitor ceritinib. CONCLUSIONS: T …
Relevant to the treatment of infant gliomas, we showed that ALK protein appears minimally expressed in the forebrain at perinatal stages, an …
Mitochondria at the neuronal presynapse in health and disease.
Devine MJ, Kittler JT. Devine MJ, et al. Nat Rev Neurosci. 2018 Jan 19;19(2):63-80. doi: 10.1038/nrn.2017.170. Nat Rev Neurosci. 2018. PMID: 29348666 Review.
Synapses enable neurons to communicate with each other and are therefore a prerequisite for normal brain function. Presynaptically, this communication requires energy and generates large fluctuations in calcium concentrations. ...
Synapses enable neurons to communicate with each other and are therefore a prerequisite for normal brain function. Presynaptically, t …
Cognition in ring-tailed lemurs.
Kittler K, Schnoell AV, Fichtel C. Kittler K, et al. Folia Primatol (Basel). 2015;86(1-2):106-116. doi: 10.1159/000368669. Epub 2015 May 19. Folia Primatol (Basel). 2015. PMID: 26022306 Free article. Review.
Compared to haplorhine primates, lemurs have relatively smaller brains and reduced abilities to solve problems in the technical and social domain. ...
Compared to haplorhine primates, lemurs have relatively smaller brains and reduced abilities to solve problems in the technical and s …
Miro1-dependent mitochondrial dynamics in parvalbumin interneurons.
Kontou G, Antonoudiou P, Podpolny M, Szulc BR, Arancibia-Carcamo IL, Higgs NF, Lopez-Domenech G, Salinas PC, Mann EO, Kittler JT. Kontou G, et al. Elife. 2021 Jun 30;10:e65215. doi: 10.7554/eLife.65215. Elife. 2021. PMID: 34190042 Free PMC article.
Here, we explore the role of Miro1 in PV+ interneurons and how changes in mitochondrial trafficking could alter network activity in the mouse brain. By employing live and fixed imaging, we found that the impairments in Miro1-directed trafficking in PV+ interneurons altered …
Here, we explore the role of Miro1 in PV+ interneurons and how changes in mitochondrial trafficking could alter network activity in the mous …
83 results