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The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.
Uynuk-Ool T, Rothdiener M, Walters B, Hegemann M, Palm J, Nguyen P, Seeger T, Stöckle U, Stegemann JP, Aicher WK, Kurz B, Hart ML, Klein G, Rolauffs B. Uynuk-Ool T, et al. Among authors: walters b. J Tissue Eng Regen Med. 2017 Dec;11(12):3508-3522. doi: 10.1002/term.2263. Epub 2017 Mar 29. J Tissue Eng Regen Med. 2017. PMID: 28371409 Free article.
Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.
Rothdiener M, Hegemann M, Uynuk-Ool T, Walters B, Papugy P, Nguyen P, Claus V, Seeger T, Stoeckle U, Boehme KA, Aicher WK, Stegemann JP, Hart ML, Kurz B, Klein G, Rolauffs B. Rothdiener M, et al. Among authors: walters b. Sci Rep. 2016 Oct 24;6:35840. doi: 10.1038/srep35840. Sci Rep. 2016. PMID: 27775041 Free PMC article.