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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1975 3
1976 4
1977 1
1978 1
1979 1
1982 3
1983 6
1984 4
1985 1
1986 8
1987 6
1988 8
1989 5
1990 10
1991 9
1992 10
1993 23
1994 14
1995 23
1996 14
1997 18
1998 19
1999 19
2000 20
2001 35
2002 26
2003 23
2004 33
2005 26
2006 41
2007 30
2008 35
2009 33
2010 29
2011 33
2012 47
2013 40
2014 45
2015 39
2016 29
2017 29
2018 34
2019 42
2020 37
2021 39
2022 38
2023 43
2024 18

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981 results

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Page 1
Watson-Crick versus Hoogsteen Base Pairs: Chemical Strategy to Encode and Express Genetic Information in Life.
Takahashi S, Sugimoto N. Takahashi S, et al. Acc Chem Res. 2021 May 4;54(9):2110-2120. doi: 10.1021/acs.accounts.0c00734. Epub 2021 Feb 16. Acc Chem Res. 2021. PMID: 33591181 Review.
Although it is well-known that Watson-Crick base pairs may be more unstable than non-Watson-Crick base pairs under some conditions, the importance of non-Watson-Crick base pairs has not been widely examined. Hoogsteen base pairs, the non-Watson-Crick b …
Although it is well-known that Watson-Crick base pairs may be more unstable than non-Watson-Crick base pairs under some condit …
"Watson-Crick G[triple bond, length as m-dash]C"-inspired supramolecular nanodrug of methotrexate and 5-fluorouracil for tumor microenvironment-activatable self-recognizing synergistic chemotherapy.
Chen M, Chen S, Zhu F, Wang F, Tian H, Fan Z, Ke S, Hou Z, Li Y. Chen M, et al. J Mater Chem B. 2020 May 6;8(17):3829-3841. doi: 10.1039/d0tb00468e. J Mater Chem B. 2020. PMID: 32232285
However, their low structural stability, lack of targeting specificity, and poor stimulus responsiveness are still limiting their therapeutic effect. Inspired by Watson-Crick G[triple bond, length as m-dash]C base pairing, the FDA-approved chemo-drug methotrexate (M …
However, their low structural stability, lack of targeting specificity, and poor stimulus responsiveness are still limiting their therapeuti …
Harnessing non-Watson-Crick's base pairing to enhance CRISPR effectors cleavage activities and enable gene editing in mammalian cells.
Gao S, Guan H, Bloomer H, Wich D, Song D, Khirallah J, Ye Z, Zhao Y, Chen M, Xu C, Liu L, Xu Q. Gao S, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2308415120. doi: 10.1073/pnas.2308415120. Epub 2023 Dec 27. Proc Natl Acad Sci U S A. 2024. PMID: 38150477
Genomic DNA of the cyanophage S-2L virus is composed of 2-aminoadenine (Z), thymine (T), guanine (G), and cytosine (C), forming the genetic alphabet ZTGC, which violates Watson-Crick base pairing rules. The Z-base has an extra amino group on the two position that allows th …
Genomic DNA of the cyanophage S-2L virus is composed of 2-aminoadenine (Z), thymine (T), guanine (G), and cytosine (C), forming the genetic …
Watson-Crick Base Pairing of N-Methoxy-1,3-Oxazinane (MOANA) Nucleoside Analogues within Double-Helical DNA.
Afari MNK, Nurmi K, Virta P, Lönnberg T. Afari MNK, et al. ChemistryOpen. 2023 Jul;12(7):e202300085. doi: 10.1002/open.202300085. ChemistryOpen. 2023. PMID: 37403132 Free PMC article.
The equilibrium of this reaction was found to be dependent on both the aldehyde and the nucleobase opposite to the modified residue. 9-Formyl-9-deazaadenine, combining a large stacking surface with an array of hydrogen bond donors and acceptors, showed the highest affinity …
The equilibrium of this reaction was found to be dependent on both the aldehyde and the nucleobase opposite to the modified residue. 9-Formy …
Intragenomic Decarboxylation of 5-Carboxy-2'-deoxycytidine.
Kamińska E, Korytiaková E, Reichl A, Müller M, Carell T. Kamińska E, et al. Angew Chem Int Ed Engl. 2021 Oct 18;60(43):23207-23211. doi: 10.1002/anie.202109995. Epub 2021 Sep 24. Angew Chem Int Ed Engl. 2021. PMID: 34432359 Free PMC article.
Cellular DNA is composed of four canonical nucleosides (dA, dC, dG and T), which form two Watson-Crick base pairs. In addition, 5-methylcytosine (mdC) may be present. ...By using metabolic labelling, we show here that cadC decarboxylates in several cell types, which confir …
Cellular DNA is composed of four canonical nucleosides (dA, dC, dG and T), which form two Watson-Crick base pairs. In addition, 5-met …
Identifying hydrogen bond alignments in multistranded DNA architectures by NMR.
Majumdar A, Patel DJ. Majumdar A, et al. Acc Chem Res. 2002 Jan;35(1):1-11. doi: 10.1021/ar010097+. Acc Chem Res. 2002. PMID: 11790083 Review.
NMR studies of nucleic acids have benefited tremendously from the discovery of trans-hydrogen-bond scalar coupling constants, which have enabled direct determination of N-H...N and N-H...O=C hydrogen bonds using a combination of (2h)J(NN)-, (4h)J(NN)-, and (3h)J(NC)-based …
NMR studies of nucleic acids have benefited tremendously from the discovery of trans-hydrogen-bond scalar coupling constants, which h …
Watson-Crick Base Pairing-Inspired Laser/GSH Activatable miRNA-Coordination Polymer Nanoplexes for Combined Cancer Chemo-Immuno-Photothermal Therapy.
Zhang J, Sun X, Zhao X, Liu L, Cheng X, Yang C, Hu H, Qiao M, Chen D, Zhao X. Zhang J, et al. ACS Appl Mater Interfaces. 2022 May 11;14(18):20762-20777. doi: 10.1021/acsami.2c03523. Epub 2022 Apr 27. ACS Appl Mater Interfaces. 2022. PMID: 35476413
Overexpressed indoleamine 2,3-dioxygenase-1 (IDO1) in tumor tissues plays a vital role in TIM generation, and downregulation of IDO1 expression may reverse TIM. Inspired by the Watson-Crick base-pairing rule, a versatile noncationic miRNA vector (miDAC@PDA) is developed fo …
Overexpressed indoleamine 2,3-dioxygenase-1 (IDO1) in tumor tissues plays a vital role in TIM generation, and downregulation of IDO1 express …
Characterization of hydrogen bond lengths in Watson-Crick base pairs by cross-correlated relaxation.
Riek R. Riek R. J Magn Reson. 2001 Mar;149(1):149-53. doi: 10.1006/jmre.2001.2291. J Magn Reson. 2001. PMID: 11273765
Hydrogen bond lengths in Watson-Crick base pairs can be characterized by cross-correlated relaxation between 1H chemical shift anisotropy and dipole-dipole coupling of 1H and its hydrogen bond acceptor 15N. As a reference, the cross-correlated relaxation betw …
Hydrogen bond lengths in Watson-Crick base pairs can be characterized by cross-correlated relaxation between 1H chemical shift …
Complexes of DNA bases and Watson-Crick base pairs with small neutral gold clusters.
Kryachko ES, Remacle F. Kryachko ES, et al. J Phys Chem B. 2005 Dec 8;109(48):22746-57. doi: 10.1021/jp054708h. J Phys Chem B. 2005. PMID: 16853964 Review.
We do so in terms of the proton affinities and deprotonation energies of those proton acceptors and proton donors which are involved in the interbase hydrogen bondings. A variety of properties of the most stable Watson-Crick [A x T]-Au3 and [G x C]-Au3 hybridized complexes …
We do so in terms of the proton affinities and deprotonation energies of those proton acceptors and proton donors which are involved in the …
Crystal structure of 1-hepta-fluoro-tolyl-closo-1,2-dicarbadodeca-borane.
Watson JD, Benton A, Tricas H, Rosair GM, Welch AJ. Watson JD, et al. Acta Crystallogr E Crystallogr Commun. 2019 Mar 29;75(Pt 4):512-515. doi: 10.1107/S2056989019004067. eCollection 2019 Apr 1. Acta Crystallogr E Crystallogr Commun. 2019. PMID: 31161066 Free PMC article.
The mol-ecular structure of the title compound 1-(2',3',5',6'-tetra-fluoro-4'-trifluoro-methyl-phen-yl)-closo-1,2-dicarbadodeca-borane, C(9)H(11)B(10)F(7), features an intra-molecular ortho-FH2 hydrogen bond [2.11 (2) A], which is responsible for an orientation of the hept …
The mol-ecular structure of the title compound 1-(2',3',5',6'-tetra-fluoro-4'-trifluoro-methyl-phen-yl)-closo-1,2-dicarbadodeca-borane, C(9) …
981 results