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mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.
Ardestani A, Lupse B, Kido Y, Leibowitz G, Maedler K. Ardestani A, et al. Among authors: lupse b. Cell Metab. 2018 Feb 6;27(2):314-331. doi: 10.1016/j.cmet.2017.11.004. Epub 2017 Dec 21. Cell Metab. 2018. PMID: 29275961 Free article. Review.
Neratinib protects pancreatic beta cells in diabetes.
Ardestani A, Li S, Annamalai K, Lupse B, Geravandi S, Dobrowolski A, Yu S, Zhu S, Baguley TD, Surakattula M, Oetjen J, Hauberg-Lotte L, Herranz R, Awal S, Altenhofen D, Nguyen-Tran V, Joseph S, Schultz PG, Chatterjee AK, Rogers N, Tremblay MS, Shen W, Maedler K. Ardestani A, et al. Among authors: lupse b. Nat Commun. 2019 Nov 1;10(1):5015. doi: 10.1038/s41467-019-12880-5. Nat Commun. 2019. PMID: 31676778 Free PMC article.
Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.
Lupse B, Annamalai K, Ibrahim H, Kaur S, Geravandi S, Sarma B, Pal A, Awal S, Joshi A, Rafizadeh S, Madduri MK, Khazaei M, Liu H, Yuan T, He W, Gorrepati KDD, Azizi Z, Qi Q, Ye K, Oberholzer J, Maedler K, Ardestani A. Lupse B, et al. Cell Rep. 2021 Aug 3;36(5):109490. doi: 10.1016/j.celrep.2021.109490. Cell Rep. 2021. PMID: 34348155 Free PMC article.
LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.
Sanchez PKM, Khazaei M, Gatineau E, Geravandi S, Lupse B, Liu H, Dringen R, Wojtusciszyn A, Gilon P, Maedler K, Ardestani A. Sanchez PKM, et al. Among authors: lupse b. Biochem Biophys Res Commun. 2021 Sep 3;568:158-166. doi: 10.1016/j.bbrc.2021.06.065. Epub 2021 Jul 1. Biochem Biophys Res Commun. 2021. PMID: 34217973 Free PMC article.
15 results