Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Chronic inflammatory demyelinating polyradiculoneuropathies (CIDP) is a type of acquired immune-mediated disorder that affects the peripheral nervous system. Although it has diverse clinical presentations, the classical presentation includes symmetric proximal and distal sensory and motor involvement. CIDP can be monophasic, relapsing, or progressive, developing over eight weeks. The time course of 8 weeks and the duration to reach nadir help distinguish CIDP from Guillain-Barre syndrome (GBS) or other acute inflammatory demyelinating polyneuropathies (AIDP). The first case was described by Eichhorst Burns in 1890. About 16% of the patients present with acute GBS.