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BMP-2 (and partially GDF-5) coating significantly accelerates and augments bone formation close to hydroxyapatite/tricalcium-phosphate/brushite implant cylinders for tibial bone defects in senile, osteopenic sheep.
Sachse A, Hasenbein I, Hortschansky P, Schmuck KD, Maenz S, Illerhaus B, Kuehmstedt P, Ramm R, Huber R, Kunisch E, Horbert V, Gunnella F, Roth A, Schubert H, Kinne RW. Sachse A, et al. Among authors: illerhaus b. J Mater Sci Mater Med. 2023 Jun 28;34(7):31. doi: 10.1007/s10856-023-06734-2. J Mater Sci Mater Med. 2023. PMID: 37378714 Free PMC article.
Enhanced bone formation in sheep vertebral bodies after minimally invasive treatment with a novel, PLGA fiber-reinforced brushite cement.
Maenz S, Brinkmann O, Kunisch E, Horbert V, Gunnella F, Bischoff S, Schubert H, Sachse A, Xin L, Günster J, Illerhaus B, Jandt KD, Bossert J, Kinne RW, Bungartz M. Maenz S, et al. Among authors: illerhaus b. Spine J. 2017 May;17(5):709-719. doi: 10.1016/j.spinee.2016.11.006. Epub 2016 Nov 15. Spine J. 2017. PMID: 27871820
The GDF5 mutant BB-1 enhances the bone formation induced by an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia.
Gunnella F, Kunisch E, Maenz S, Horbert V, Xin L, Mika J, Borowski J, Bischoff S, Schubert H, Sachse A, Illerhaus B, Günster J, Bossert J, Jandt KD, Plöger F, Kinne RW, Brinkmann O, Bungartz M. Gunnella F, et al. Among authors: illerhaus b. Spine J. 2018 Feb;18(2):357-369. doi: 10.1016/j.spinee.2017.10.002. Epub 2017 Oct 12. Spine J. 2018. PMID: 29031993
GDF5 significantly augments the bone formation induced by an injectable, PLGA fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia.
Bungartz M, Kunisch E, Maenz S, Horbert V, Xin L, Gunnella F, Mika J, Borowski J, Bischoff S, Schubert H, Sachse A, Illerhaus B, Günster J, Bossert J, Jandt KD, Plöger F, Kinne RW, Brinkmann O. Bungartz M, et al. Among authors: illerhaus b. Spine J. 2017 Nov;17(11):1685-1698. doi: 10.1016/j.spinee.2017.06.007. Epub 2017 Jun 19. Spine J. 2017. PMID: 28642196
Low-dose BMP-2 is sufficient to enhance the bone formation induced by an injectable, PLGA fiber-reinforced, brushite-forming cement in a sheep defect model of lumbar osteopenia.
Gunnella F, Kunisch E, Bungartz M, Maenz S, Horbert V, Xin L, Mika J, Borowski J, Bischoff S, Schubert H, Hortschansky P, Sachse A, Illerhaus B, Günster J, Bossert J, Jandt KD, Plöger F, Kinne RW, Brinkmann O. Gunnella F, et al. Among authors: illerhaus b. Spine J. 2017 Nov;17(11):1699-1711. doi: 10.1016/j.spinee.2017.06.005. Epub 2017 Jun 12. Spine J. 2017. PMID: 28619686
Decreased extrusion of calcium phosphate cement versus high viscosity PMMA cement into spongious bone marrow-an ex vivo and in vivo study in sheep vertebrae.
Xin L, Bungartz M, Maenz S, Horbert V, Hennig M, Illerhaus B, Günster J, Bossert J, Bischoff S, Borowski J, Schubert H, Jandt KD, Kunisch E, Kinne RW, Brinkmann O. Xin L, et al. Among authors: illerhaus b. Spine J. 2016 Dec;16(12):1468-1477. doi: 10.1016/j.spinee.2016.07.529. Epub 2016 Aug 2. Spine J. 2016. PMID: 27496285
First-time systematic postoperative clinical assessment of a minimally invasive approach for lumbar ventrolateral vertebroplasty in the large animal model sheep.
Bungartz M, Maenz S, Kunisch E, Horbert V, Xin L, Gunnella F, Mika J, Borowski J, Bischoff S, Schubert H, Sachse A, Illerhaus B, Günster J, Bossert J, Jandt KD, Kinne RW, Brinkmann O. Bungartz M, et al. Among authors: illerhaus b. Spine J. 2016 Oct;16(10):1263-1275. doi: 10.1016/j.spinee.2016.06.015. Epub 2016 Jun 23. Spine J. 2016. PMID: 27345746