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Page 1
4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors.
Eur J Med Chem. 2020 Dec 15;208:112720. doi: 10.1016/j.ejmech.2020.112720. Epub 2020 Aug 20.
Eur J Med Chem. 2020.
PMID: 32937203
Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors.
Kufareva I, Bestgen B, Brear P, Prudent R, Laudet B, Moucadel V, Ettaoussi M, Sautel CF, Krimm I, Engel M, Filhol O, Borgne ML, Lomberget T, Cochet C, Abagyan R.
Kufareva I, et al. Among authors: bestgen b.
Sci Rep. 2019 Nov 4;9(1):15893. doi: 10.1038/s41598-019-52141-5.
Sci Rep. 2019.
PMID: 31685885
Free PMC article.
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2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site.
Bestgen B, Krimm I, Kufareva I, Kamal AAM, Seetoh WG, Abell C, Hartmann RW, Abagyan R, Cochet C, Le Borgne M, Engel M, Lomberget T.
Bestgen B, et al.
J Med Chem. 2019 Feb 28;62(4):1803-1816. doi: 10.1021/acs.jmedchem.8b01766. Epub 2019 Feb 18.
J Med Chem. 2019.
PMID: 30689953
Free PMC article.
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In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface.
Bestgen B, Belaid-Choucair Z, Lomberget T, Le Borgne M, Filhol O, Cochet C.
Bestgen B, et al.
Pharmaceuticals (Basel). 2017 Feb 3;10(1):16. doi: 10.3390/ph10010016.
Pharmaceuticals (Basel). 2017.
PMID: 28165359
Free PMC article.
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Rational Design, Synthesis, and Biological Evaluation of 7-Azaindole Derivatives as Potent Focused Multi-Targeted Kinase Inhibitors.
Daydé-Cazals B, Fauvel B, Singer M, Feneyrolles C, Bestgen B, Gassiot F, Spenlinhauer A, Warnault P, Van Hijfte N, Borjini N, Chevé G, Yasri A.
Daydé-Cazals B, et al. Among authors: bestgen b.
J Med Chem. 2016 Apr 28;59(8):3886-905. doi: 10.1021/acs.jmedchem.6b00087. Epub 2016 Apr 15.
J Med Chem. 2016.
PMID: 27010810
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2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action.
Bestgen B, Kufareva I, Seetoh W, Abell C, Hartmann RW, Abagyan R, Le Borgne M, Filhol O, Cochet C, Lomberget T, Engel M.
Bestgen B, et al.
J Med Chem. 2019 Feb 28;62(4):1817-1836. doi: 10.1021/acs.jmedchem.8b01765. Epub 2019 Feb 13.
J Med Chem. 2019.
PMID: 30689946
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