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Year Number of Results
1999 3
2002 1
2006 1
2007 2
2008 1
2009 2
2010 2
2011 1
2012 1
2015 3
2017 3
2018 1
2019 2
2020 1
2021 3
2022 5
2023 3
2024 1

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35 results

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Page 1
Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells.
Gattinoni L, Zhong XS, Palmer DC, Ji Y, Hinrichs CS, Yu Z, Wrzesinski C, Boni A, Cassard L, Garvin LM, Paulos CM, Muranski P, Restifo NP. Gattinoni L, et al. Nat Med. 2009 Jul;15(7):808-13. doi: 10.1038/nm.1982. Epub 2009 Jun 14. Nat Med. 2009. PMID: 19525962 Free PMC article.
Self-renewing cell populations such as hematopoietic stem cells and memory B and T lymphocytes might be regulated by shared signaling pathways. ...
Self-renewing cell populations such as hematopoietic stem cells and memory B and T lymphocytes might be regulated by shared signaling …
B cells imprint adoptively transferred CD8(+) T cells with enhanced tumor immunity.
Smith AS, Knochelmann HM, Wyatt MM, Rangel Rivera GO, Rivera-Reyes AM, Dwyer CJ, Ware MB, Cole AC, Neskey DM, Rubinstein MP, Liu B, Thaxton JE, Bartee E, Paulos CM. Smith AS, et al. J Immunother Cancer. 2022 Jan;10(1):e003078. doi: 10.1136/jitc-2021-003078. J Immunother Cancer. 2022. PMID: 35017148 Free PMC article.
RESULTS: Herein we reveal a new way to reverse the tolerant state of adoptively transferred CD8(+) T cells against tumors using TLR-activated B cells. We repurposed the TLR9 agonist, CpG, commonly used in the clinic, to bolster T cell-B cell interactions during expa …
RESULTS: Herein we reveal a new way to reverse the tolerant state of adoptively transferred CD8(+) T cells against tumors using TLR-activate …
Perspectives in Immunotherapy: meeting report from Immunotherapy Bridge (Naples, November 30th-December 1st, 2022).
Ascierto PA, Avallone A, Bifulco C, Bracarda S, Brody JD, Emens LA, Ferris RL, Formenti SC, Hamid O, Johnson DB, Kirchhoff T, Klebanoff CA, Lesinski GB, Monette A, Neyns B, Odunsi K, Paulos CM, Powell DJ Jr, Rezvani K, Segal BH, Singh N, Sullivan RJ, Fox BA, Puzanov I. Ascierto PA, et al. J Transl Med. 2023 Jul 20;21(1):488. doi: 10.1186/s12967-023-04329-7. J Transl Med. 2023. PMID: 37475035 Free PMC article.
A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves BP, Jassat W, Baruch J, Hashmi M, Rojek A, Dasgupta A, Martin-Loeches I, Reyes LF, Piubelli C, Citarella BW, Kartsonaki C, Lefèvre B, López Revilla JW, Lunn M, Harrison EM, Kraemer MUG, Shrapnel S, Horby P, Bisoffi Z, Olliaro PL, Merson L; ISARIC Clinical Characterisation Group. Gonçalves BP, et al. Med. 2023 Nov 10;4(11):797-812.e2. doi: 10.1016/j.medj.2023.08.005. Epub 2023 Sep 21. Med. 2023. PMID: 37738979 Free PMC article.
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19.
ISARIC Clinical Characterization Group; Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. ISARIC Clinical Characterization Group, et al. Sci Data. 2022 Jul 30;9(1):454. doi: 10.1038/s41597-022-01534-9. Sci Data. 2022. PMID: 35908040 Free PMC article.
Safety, immunological effects and clinical response in a phase I trial of umbilical cord mesenchymal stromal cells in patients with treatment refractory SLE.
Kamen DL, Wallace C, Li Z, Wyatt M, Paulos C, Wei C, Wang H, Wolf BJ, Nietert PJ, Gilkeson G. Kamen DL, et al. Lupus Sci Med. 2022 Jul;9(1):e000704. doi: 10.1136/lupus-2022-000704. Lupus Sci Med. 2022. PMID: 35820718 Free PMC article. Clinical Trial.
Mechanistic studies revealed significant reductions in CD27IgD double negative B cells, switched memory B cells and activated naive B cells, with increased transitional B cells in the five patients who met the endpoint. ...GARP-TGFbeta complexes were s …
Mechanistic studies revealed significant reductions in CD27IgD double negative B cells, switched memory B cells and activated …
Toll-like receptors in tumor immunotherapy.
Paulos CM, Kaiser A, Wrzesinski C, Hinrichs CS, Cassard L, Boni A, Muranski P, Sanchez-Perez L, Palmer DC, Yu Z, Antony PA, Gattinoni L, Rosenberg SA, Restifo NP. Paulos CM, et al. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5280-9. doi: 10.1158/1078-0432.CCR-07-1378. Clin Cancer Res. 2007. PMID: 17875756 Free PMC article. Review.
Emerging data indicate that the key mechanisms underlying how TBI augments the functions of adoptively transferred T cells include (a) the depletion of regulatory T cells (T(reg)) and myeloid-derived suppressor cells that limit the function and proliferation of adoptively transfe …
Emerging data indicate that the key mechanisms underlying how TBI augments the functions of adoptively transferred T cells include (a) the d …
Combined MEK/PD-L1 Inhibition Alters Peripheral Cytokines and Lymphocyte Populations Correlating with Improved Clinical Outcomes in Advanced Biliary Tract Cancer.
Ruggieri AN, Yarchoan M, Goyal S, Liu Y, Sharon E, Chen HX, Olson BM, Paulos CM, El-Rayes BF, Maithel SK, Azad NS, Lesinski GB. Ruggieri AN, et al. Clin Cancer Res. 2022 Oct 3;28(19):4336-4345. doi: 10.1158/1078-0432.CCR-22-1123. Clin Cancer Res. 2022. PMID: 35833954 Free PMC article. Clinical Trial.
RESULTS: At baseline, the soluble factors platelet-derived growth factor B (PDGF)-BB, placental growth factor (PlGF)-1, IL5, and IL17A were elevated in patients with BTC compared with healthy adult donors, and higher baseline frequencies of CD8+BTLA+ T cells correlated wit …
RESULTS: At baseline, the soluble factors platelet-derived growth factor B (PDGF)-BB, placental growth factor (PlGF)-1, IL5, and IL17 …
35 results