Deep thermal profiling for detection of functional proteoform groups.
Kurzawa N, Leo IR, Stahl M, Kunold E, Becher I, Audrey A, Mermelekas G, Huber W, Mateus A, Savitski MM, Jafari R.
Kurzawa N, et al.
Nat Chem Biol. 2023 Aug;19(8):962-971. doi: 10.1038/s41589-023-01284-8. Epub 2023 Mar 20.
Nat Chem Biol. 2023.
PMID: 36941476
Free PMC article.
We identified differential co-aggregation of proteoform pairs and established links to disease biology. Moreover, we systematically made use of measured biophysical proteoform states to find specific biomarkers of drug sensitivity. ...
We identified differential co-aggregation of proteoform pairs and established links to disease biology. Moreover, we systematically m …