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Page 1
Identification of a novel allosteric GLP-1R antagonist HTL26119 using structure- based drug design.
O'Brien A, Andrews SP, Baig AH, Bortolato A, Brown AJH, Brown GA, Brown SH, Christopher JA, Congreve M, Cooke RM, De Graaf C, Errey JC, Fieldhouse C, Jazayeri A, Marshall FH, Mason JS, Mobarec JC, Okrasa K, Steele KN, Southall SM, Teobald I, Watson SP, Weir M. O'Brien A, et al. Among authors: baig ah. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126611. doi: 10.1016/j.bmcl.2019.08.015. Epub 2019 Aug 9. Bioorg Med Chem Lett. 2019. PMID: 31447084
Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities.
Audouze K, Zgheib E, Abass K, Baig AH, Forner-Piquer I, Holbech H, Knapen D, Leonards PEG, Lupu DI, Palaniswamy S, Rautio A, Sapounidou M, Martin OV. Audouze K, et al. Among authors: baig ah. Front Toxicol. 2021 Dec 21;3:787017. doi: 10.3389/ftox.2021.787017. eCollection 2021. Front Toxicol. 2021. PMID: 35295112 Free PMC article. No abstract available.
Extra-helical binding site of a glucagon receptor antagonist.
Jazayeri A, Doré AS, Lamb D, Krishnamurthy H, Southall SM, Baig AH, Bortolato A, Koglin M, Robertson NJ, Errey JC, Andrews SP, Teobald I, Brown AJ, Cooke RM, Weir M, Marshall FH. Jazayeri A, et al. Among authors: baig ah. Nature. 2016 May 12;533(7602):274-7. doi: 10.1038/nature17414. Epub 2016 Apr 25. Nature. 2016. PMID: 27111510
Crystal structure of the GLP-1 receptor bound to a peptide agonist.
Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Doré AS, Weir M, Cooke RM, Marshall FH. Jazayeri A, et al. Among authors: baig ah. Nature. 2017 Jun 8;546(7657):254-258. doi: 10.1038/nature22800. Epub 2017 May 31. Nature. 2017. PMID: 28562585
Corrigendum: Crystal structure of the GLP-1 receptor bound to a peptide agonist.
Jazayeri A, Rappas M, Brown AJH, Kean J, Errey JC, Robertson NJ, Fiez-Vandal C, Andrews SP, Congreve M, Bortolato A, Mason JS, Baig AH, Teobald I, Doré AS, Weir M, Cooke RM, Marshall FH. Jazayeri A, et al. Among authors: baig ah. Nature. 2017 Aug 3;548(7665):122. doi: 10.1038/nature23311. Epub 2017 Jul 12. Nature. 2017. PMID: 28700581
Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project.
Kortenkamp A, Axelstad M, Baig AH, Bergman Å, Bornehag CG, Cenijn P, Christiansen S, Demeneix B, Derakhshan A, Fini JB, Frädrich C, Hamers T, Hellwig L, Köhrle J, Korevaar TIM, Lindberg J, Martin O, Meima ME, Mergenthaler P, Nikolov N, Du Pasquier D, Peeters RP, Platzack B, Ramhøj L, Remaud S, Renko K, Scholze M, Stachelscheid H, Svingen T, Wagenaars F, Wedebye EB, Zoeller RT. Kortenkamp A, et al. Among authors: baig ah. Int J Mol Sci. 2020 Apr 28;21(9):3123. doi: 10.3390/ijms21093123. Int J Mol Sci. 2020. PMID: 32354186 Free PMC article.