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Showing results for ashfaq e. Alam
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Dexamethasone in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17. N Engl J Med. 2021. PMID: 32678530 Free PMC article. Clinical Trial.
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19.
RECOVERY Collaborative Group; Horby P, Mafham M, Linsell L, Bell JL, Staplin N, Emberson JR, Wiselka M, Ustianowski A, Elmahi E, Prudon B, Whitehouse T, Felton T, Williams J, Faccenda J, Underwood J, Baillie JK, Chappell LC, Faust SN, Jaki T, Jeffery K, Lim WS, Montgomery A, Rowan K, Tarning J, Watson JA, White NJ, Juszczak E, Haynes R, Landray MJ. RECOVERY Collaborative Group, et al. N Engl J Med. 2020 Nov 19;383(21):2030-2040. doi: 10.1056/NEJMoa2022926. Epub 2020 Oct 8. N Engl J Med. 2020. PMID: 33031652 Free PMC article. Clinical Trial.
Discovery of Amide-Functionalized Benzimidazolium Salts as Potent α-Glucosidase Inhibitors.
Khan IA, Ahmad M, Ashfaq UA, Sultan S, Zaki MEA. Khan IA, et al. Molecules. 2021 Aug 6;26(16):4760. doi: 10.3390/molecules26164760. Molecules. 2021. PMID: 34443347 Free PMC article.
The aim of this study is to explore the alpha-glucosidase inhibition ability of benzimidazolium salts. In this study, two novel series of benzimidazolium salts, i.e., 1-benzyl-3-{2-(substituted) amino-2-oxoethyl}-1H-benzo[d]imidazol-3-ium bromide 9a-m and 1-benzyl-3-{2-sub …
The aim of this study is to explore the alpha-glucosidase inhibition ability of benzimidazolium salts. In this study, two novel series of be …
An increase in AMPK/e-NOS signaling and attenuation of MMP-9 may contribute to remote ischemic perconditioning associated neuroprotection in rat model of focal ischemia.
Parray A, Ma Y, Alam M, Akhtar N, Salam A, Mir F, Qadri S, Pananchikkal SV, Priyanka R, Kamran S, Winship IR, Shuaib A. Parray A, et al. Brain Res. 2020 Aug 1;1740:146860. doi: 10.1016/j.brainres.2020.146860. Epub 2020 Apr 27. Brain Res. 2020. PMID: 32353433
Here we explore if RIPerC improves neuroprotection and collateral flow by modifying the activities of MMP-9 and AMPK/e-NOS. Age matched adult male Sprague Dawley rats were subjected to MCAO followed one hour later by RIPerC (3 cycles of 15 min ischemia). Animals were eutha …
Here we explore if RIPerC improves neuroprotection and collateral flow by modifying the activities of MMP-9 and AMPK/e-NOS. Age match …
Identification of Cyclic Sulfonamides with an N-Arylacetamide Group as α-Glucosidase and α-Amylase Inhibitors: Biological Evaluation and Molecular Modeling.
Saddique FA, Ahmad M, Ashfaq UA, Muddassar M, Sultan S, Zaki MEA. Saddique FA, et al. Pharmaceuticals (Basel). 2022 Jan 17;15(1):106. doi: 10.3390/ph15010106. Pharmaceuticals (Basel). 2022. PMID: 35056163 Free PMC article.
Diversified 2-(3-(3-methoxybenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides were synthesized and evaluated for their in vitro inhibitory potential against alpha-glucosidase and alpha-amylase enzymes. ...In addition, the most potent compound, N- …
Diversified 2-(3-(3-methoxybenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides were synthesized and evaluat …
A synthetic approach towards drug modification: 2-hydroxy-1-naphthaldehyde based imine-zwitterion preparation, single-crystal study, Hirshfeld surface analysis, and computational investigation.
Malik AN, Ali A, Ashfaq M, Tahir MN, Alam MM, Mostafa MS, Kuznetsov A. Malik AN, et al. RSC Adv. 2024 Feb 21;14(10):6476-6493. doi: 10.1039/d3ra08727a. eCollection 2024 Feb 21. RSC Adv. 2024. PMID: 38390507 Free PMC article.
The current work is about the modification of primary amine functionalized drugs, pyrimethamine and 4-amino-N-(2,3-dihydrothiazol-2-yl)benzenesulfonamide, via condensation reaction with 2-hydroxy-1-naphthaldehyde to produce new organic zwitterionic compounds (E)-1-(((4-(N- …
The current work is about the modification of primary amine functionalized drugs, pyrimethamine and 4-amino-N-(2,3-dihydrothiazol-2-yl)benze …
Synthesis and alpha-Glucosidase Inhibition Activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl]-N-arylacetamides: An In Silico and Biochemical Approach.
Saddique FA, Aslam S, Ahmad M, Ashfaq UA, Muddassar M, Sultan S, Taj S, Hussain M, Sung Lee D, Zaki MEA. Saddique FA, et al. Molecules. 2021 May 20;26(10):3043. doi: 10.3390/molecules26103043. Molecules. 2021. PMID: 34065194 Free PMC article.
We have synthesized novel 2-(3-(benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides and have screened them for their in silico and in vitro alpha-glucosidase inhibition activity. ...
We have synthesized novel 2-(3-(benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides and have …