Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity

Olga A Kraevaya; Artem V Novikov; Alexander F Shestakov; Elizaveta S Ershova; Ekaterina A Savinova; Larisa V Kameneva; Nataliya N Veiko; Dominique Schols; Jan Balzarini; Svetlana V Kostyuk; Pavel A Troshin

doi:10.1039/d0cc03928d

Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity

Chem Commun (Camb). 2020 Sep 1;56(70):10203-10206. doi: 10.1039/d0cc03928d.

Affiliations

¹ Skolkovo Institute of Science and Technology, Nobel St. 3, Moscow, 143026, Russia. okraevaya@inbox.ru and IPCP RAS, Semenov Prospect 1, Chernogolovka, 142432, Russia.
² IPCP RAS, Semenov Prospect 1, Chernogolovka, 142432, Russia and Department of Physical and Chemical Engineering, Lomonosov Moscow State University, 115478, Moscow, Russia.
³ Research Centre for Medical Genetics RAMS, Moskvorech'e St. 1, Moscow, 115478, Russia.
⁴ Rega Institute for Medical Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

PMID: 32748905
DOI: 10.1039/d0cc03928d

Abstract

Here we report a straightforward method for the synthesis of a water-soluble C60 fullerene derivative decorated with five residues of phosphonic acid. Self-assembly of the synthesized compound in aqueous solution leads to the formation of nanostructures with unprecedented myogenic and antiviral activity.

MeSH terms

Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Cell Line
Fullerenes / chemistry*
Fullerenes / pharmacology*
Humans
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / drug effects
Muscle Development / drug effects*
Nanostructures / chemistry*
Solubility
Water / chemistry*

Substances

Antiviral Agents
Fullerenes
Water