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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1908 1
1950 3
1951 1
1952 2
1954 1
1955 1
1969 2
1970 1
1972 1
1974 2
1975 1
1976 2
1978 1
1980 1
1981 1
1982 7
1983 8
1984 10
1985 7
1986 9
1987 12
1988 10
1989 5
1990 2
1991 11
1992 7
1993 4
1994 6
1995 15
1996 24
1997 39
1998 44
1999 44
2000 33
2001 39
2002 43
2003 42
2004 41
2005 38
2006 39
2007 44
2008 49
2009 36
2010 55
2011 39
2012 58
2013 62
2014 69
2015 59
2016 49
2017 51
2018 56
2019 71
2020 69
2021 84
2022 81
2023 99
2024 39

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1,489 results

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Page 1
T cell activation.
Smith-Garvin JE, Koretzky GA, Jordan MS. Smith-Garvin JE, et al. Annu Rev Immunol. 2009;27:591-619. doi: 10.1146/annurev.immunol.021908.132706. Annu Rev Immunol. 2009. PMID: 19132916 Free PMC article. Review.
This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings examining other key aspects of T cell activation, including cross talk between the TCR and integrins, the role of costimulatory mole …
This review continues with a description of the current state of our understanding of TCR signaling, as well as a summary of recent findings …
Role of platelets and platelet receptors in cancer metastasis.
Schlesinger M. Schlesinger M. J Hematol Oncol. 2018 Oct 11;11(1):125. doi: 10.1186/s13045-018-0669-2. J Hematol Oncol. 2018. PMID: 30305116 Free PMC article. Review.
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on platelet adhesion receptors and their role in metastasis. Immunoreceptor tyrosine-based activation motif (ITA …
This review provides a synopsis on the current literature on platelet-mediated effects in cancer metastasis and particularly focuses on plat …
Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. Feucht J, et al. Nat Med. 2019 Jan;25(1):82-88. doi: 10.1038/s41591-018-0290-5. Epub 2018 Dec 17. Nat Med. 2019. PMID: 30559421 Free PMC article.
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and differentiation. Here, we show that CARs encoding a single immunoreceptor tyrosine-based activation motif …
Thus, we hypothesized that calibrating the activation potential of CD28-based CARs would differentially reprogram T cell function and …
A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury.
Burkard P, Schonhart C, Vögtle T, Köhler D, Tang L, Johnson D, Hemmen K, Heinze KG, Zarbock A, Hermanns HM, Rosenberger P, Nieswandt B. Burkard P, et al. Blood. 2023 Oct 26;142(17):1463-1477. doi: 10.1182/blood.2023019940. Blood. 2023. PMID: 37441848
Platelets have been implicated in the pathogenesis of ALI/ARDS, but the underlying mechanisms are not fully understood. Here, we show that the immunoreceptor tyrosine-based activation motif-coupled immunoglobulin-like platelet receptor, glycopro …
Platelets have been implicated in the pathogenesis of ALI/ARDS, but the underlying mechanisms are not fully understood. Here, we show that t …
Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived galectin-3.
Mammadova-Bach E, Gil-Pulido J, Sarukhanyan E, Burkard P, Shityakov S, Schonhart C, Stegner D, Remer K, Nurden P, Nurden AT, Dandekar T, Nehez L, Dank M, Braun A, Mezzano D, Abrams SI, Nieswandt B. Mammadova-Bach E, et al. Blood. 2020 Apr 2;135(14):1146-1160. doi: 10.1182/blood.2019002649. Blood. 2020. PMID: 32040544 Free article.
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin that triggers platelet activation through immunoreceptor tyrosine-based activation motif (ITAM) signaling and thereby regulates diverse functions, including pl …
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin that triggers platelet activation through immunorec …
The TREM-1/DAP12 pathway.
Tessarz AS, Cerwenka A. Tessarz AS, et al. Immunol Lett. 2008 Mar 15;116(2):111-6. doi: 10.1016/j.imlet.2007.11.021. Epub 2007 Dec 26. Immunol Lett. 2008. PMID: 18192027 Review.
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter, which couples to multiple receptors expressed on natural killer (NK) cells, monocytes, and neutrophils. ...
DNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITA …
RBP-J and ITAM crosstalk.
Zhao B. Zhao B. Oncotarget. 2015 Nov 3;6(34):35135-6. doi: 10.18632/oncotarget.6034. Oncotarget. 2015. PMID: 26459387 Free PMC article. No abstract available.
Molecular mechanisms of immunoreceptors in platelets.
Kuriri FA, O'Malley CJ, Jackson DE. Kuriri FA, et al. Thromb Res. 2019 Apr;176:108-114. doi: 10.1016/j.thromres.2019.01.019. Epub 2019 Feb 10. Thromb Res. 2019. PMID: 30802692 Review.
Naturally, bioactive mediators are released from endothelial cells to prevent and control platelet activation. However, when the vascular endothelium is ruptured, the local concentration of nitric oxide and prostaglandin is diminished and receptors containing a sequence of …
Naturally, bioactive mediators are released from endothelial cells to prevent and control platelet activation. However, when the vasc …
Structural understanding of T cell receptor triggering.
Xu X, Li H, Xu C. Xu X, et al. Cell Mol Immunol. 2020 Mar;17(3):193-202. doi: 10.1038/s41423-020-0367-1. Epub 2020 Feb 11. Cell Mol Immunol. 2020. PMID: 32047259 Free PMC article. Review.
Engagement of TCRalphabeta with an antigen peptide presented on the MHC leads to tyrosine phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) in CD3 cytoplasmic domains (CDs), thus translating extracellular binding kinet …
Engagement of TCRalphabeta with an antigen peptide presented on the MHC leads to tyrosine phosphorylation of the immunoreceptor ty …
Siglec functions of microglia.
Linnartz-Gerlach B, Kopatz J, Neumann H. Linnartz-Gerlach B, et al. Glycobiology. 2014 Sep;24(9):794-9. doi: 10.1093/glycob/cwu044. Epub 2014 May 15. Glycobiology. 2014. PMID: 24833613 Review.
Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. Most Siglecs contain an immunoreceptor tyrosine based inhibition motif and its signaling leads to the terminati …
Therefore, microglia need recognition receptors that lead to either the activation or the inhibition of the immune response pathways. …
1,489 results