Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction

Mohammed Sikander; Shabnam Malik; Anyssa Rodriguez; Murali M Yallapu; Acharan S Narula; Sanjaya K Satapathy; Vijian Dhevan; Subhash C Chauhan; Meena Jaggi

doi:10.3390/molecules25245905

Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction

Molecules. 2020 Dec 13;25(24):5905. doi: 10.3390/molecules25245905.

Authors

Mohammed Sikander^{1

2}, Shabnam Malik^{1

2}, Anyssa Rodriguez^{1

2}, Murali M Yallapu^{1

2}, Acharan S Narula³, Sanjaya K Satapathy⁴, Vijian Dhevan⁵, Subhash C Chauhan^{1

2}, Meena Jaggi^{1

2}

Affiliations

¹ Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
² South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA.
³ Narula Research, LLC, 107 Boulder Bluff, Chapel Hill, NC 27516, USA.
⁴ Division of Hepatology, Department of Internal Medicine, Sandra Atlas Bass Center for Liver Diseases and Transplantation, Barbara and Zucker School of Medicine, Northwell Health, Manhasset, NY 11030, USA.
⁵ Department of Surgery, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USA.

Abstract

COVID-19 is known as one of the deadliest pandemics of the century. The rapid spread of this deadly virus at incredible speed has stunned the planet and poses a challenge to global scientific and medical communities. Patients with COVID-19 are at an increased risk of co-morbidities associated with liver dysfunction and injury. Moreover, hepatotoxicity induced by antiviral therapy is gaining importance and is an area of great concern. Currently, alternatives therapies are being sought to mitigate hepatic damage, and there has been growing interest in the research on bioactive phytochemical agents (nutraceuticals) due to their versatility in health benefits reported in various epidemiological studies. Therefore, this review provides information and summarizes the juncture of antiviral, immunomodulatory, and hepatoprotective nutraceuticals that can be useful during the management of COVID-19.

Keywords: ACE2; COVID-19; SARS-CoV-2; coronavirus; hepatic dysfunctions; hepatoprotective agents; nutraceuticals.

Publication types

Review

MeSH terms

Antiviral Agents* / adverse effects
Antiviral Agents* / therapeutic use
COVID-19 Drug Treatment*
COVID-19* / epidemiology
Chemical and Drug Induced Liver Injury* / diet therapy
Chemical and Drug Induced Liver Injury* / epidemiology
Dietary Supplements*
Humans
Pandemics*
SARS-CoV-2*

Substances

Antiviral Agents

Grants and funding

R01 CA210192/NH/NIH HHS/United States