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Page 1
Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria.
Biagini GA, Fisher N, Shone AE, Mubaraki MA, Srivastava A, Hill A, Antoine T, Warman AJ, Davies J, Pidathala C, Amewu RK, Leung SC, Sharma R, Gibbons P, Hong DW, Pacorel B, Lawrenson AS, Charoensutthivarakul S, Taylor L, Berger O, Mbekeani A, Stocks PA, Nixon GL, Chadwick J, Hemingway J, Delves MJ, Sinden RE, Zeeman AM, Kocken CH, Berry NG, O'Neill PM, Ward SA. Biagini GA, et al. Among authors: antoine t. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8298-303. doi: 10.1073/pnas.1205651109. Epub 2012 May 7. Proc Natl Acad Sci U S A. 2012. PMID: 22566611 Free PMC article.
HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.
Vallières C, Fisher N, Antoine T, Al-Helal M, Stocks P, Berry NG, Lawrenson AS, Ward SA, O'Neill PM, Biagini GA, Meunier B. Vallières C, et al. Among authors: antoine t. Antimicrob Agents Chemother. 2012 Jul;56(7):3739-47. doi: 10.1128/AAC.00486-12. Epub 2012 Apr 30. Antimicrob Agents Chemother. 2012. PMID: 22547613 Free PMC article.
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.
Fisher N, Abd Majid R, Antoine T, Al-Helal M, Warman AJ, Johnson DJ, Lawrenson AS, Ranson H, O'Neill PM, Ward SA, Biagini GA. Fisher N, et al. Among authors: antoine t. J Biol Chem. 2012 Mar 23;287(13):9731-9741. doi: 10.1074/jbc.M111.324319. Epub 2012 Jan 26. J Biol Chem. 2012. PMID: 22282497 Free PMC article.
Genome dedoubling by DCJ and reversal.
Thomas A, Varré JS, Ouangraoua A. Thomas A, et al. BMC Bioinformatics. 2011 Oct 5;12 Suppl 9(Suppl 9):S20. doi: 10.1186/1471-2105-12-S9-S20. BMC Bioinformatics. 2011. PMID: 22152053 Free PMC article.