Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols

Molecules. 2016 Sep 28;21(10):1295. doi: 10.3390/molecules21101295.

Abstract

The Pd-catalyzed direct alkylation of H-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to H-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds R¹R²P(O)H.

Keywords: H-phosphinate esters; alcohols; allylation; benzylation; cross-coupling; palladium.