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Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections.
Cell Host Microbe. 2023 May 10;31(5):751-765.e11. doi: 10.1016/j.chom.2023.04.004. Epub 2023 Apr 24.
Cell Host Microbe. 2023.
PMID: 37098341
Free article.
Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria.
Zhuang Z, Wan D, Ding J, He S, Zhang Q, Wang X, Yuan Y, Lu Y, Ding CZ, Lynch AS, Upton AM, Cooper CB, Denny WA, Ma Z.
Zhuang Z, et al. Among authors: lynch as.
Molecules. 2020 May 22;25(10):2431. doi: 10.3390/molecules25102431.
Molecules. 2020.
PMID: 32456032
Free PMC article.
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Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, Duncan L, Doyle T, Ebright RH, Lynch AS.
Ma Z, et al. Among authors: lynch as.
J Med Chem. 2022 Mar 24;65(6):4481-4495. doi: 10.1021/acs.jmedchem.1c02045. Epub 2022 Feb 17.
J Med Chem. 2022.
PMID: 35175750
Free PMC article.
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Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus.
Chan R, Buckley PT, O'Malley A, Sause WE, Alonzo F 3rd, Lubkin A, Boguslawski KM, Payne A, Fernandez J, Strohl WR, Whitaker B, Lynch AS, Torres VJ.
Chan R, et al. Among authors: lynch as.
Sci Transl Med. 2019 Jan 16;11(475):eaat0882. doi: 10.1126/scitranslmed.aat0882.
Sci Transl Med. 2019.
PMID: 30651319
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Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice.
Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ.
Lubkin A, et al. Among authors: lynch as.
Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. doi: 10.1016/j.chom.2019.01.015. Epub 2019 Feb 21.
Cell Host Microbe. 2019.
PMID: 30799265
Free PMC article.
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Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections.
Ma Z, Lynch AS.
Ma Z, et al. Among authors: lynch as.
J Med Chem. 2016 Jul 28;59(14):6645-57. doi: 10.1021/acs.jmedchem.6b00485. Epub 2016 Jul 9.
J Med Chem. 2016.
PMID: 27336583
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