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Inhibition of FGF2-Mediated Signaling in GIST-Promising Approach for Overcoming Resistance to Imatinib.
Boichuk S, Galembikova A, Mikheeva E, Bikinieva F, Aukhadieva A, Dunaev P, Khalikov D, Petrov S, Kurtasanov R, Valeeva E, Kireev I, Dugina V, Lushnikova A, Novikova M, Kopnin P. Boichuk S, et al. Among authors: lushnikova a. Cancers (Basel). 2020 Jun 24;12(6):1674. doi: 10.3390/cancers12061674. Cancers (Basel). 2020. PMID: 32599808 Free PMC article. Review.
A novel glycosylated indolocarbazole derivative LCS1269 effectively inhibits growth of human cancer cells in vitro and in vivo through driving of both apoptosis and senescence by inducing of DNA damage and modulating of AKT/mTOR/S6K and ERK pathways.
Kalitin NN, Ektova LV, Kostritsa NS, Sivirinova AS, Kostarev AV, Smirnova GB, Borisova YA, Golubeva IS, Ermolaeva EV, Vergun MA, Babaeva MA, Lushnikova AA, Karamysheva AF. Kalitin NN, et al. Among authors: lushnikova aa. Chem Biol Interact. 2022 Sep 1;364:110056. doi: 10.1016/j.cbi.2022.110056. Epub 2022 Jul 21. Chem Biol Interact. 2022. PMID: 35872044