Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

Affiliations

• ¹ Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
• ² Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.
• ³ Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
• ⁴ Toronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
• ⁵ Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
• ⁶ Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
• ⁷ Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
• ⁸ Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
• ⁹ HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
• ¹⁰ Center for Precision Health Research, National Human Genome Research Institute, Bethesda, MD, USA.
• ¹¹ Altman Clinical & Translational Research Institute, UC San Diego Health Sciences, San Diego, CA, USA.
• ¹² Georgetown University School of Medicine, Washington, DC, USA.
• ¹³ Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO, USA.
• ¹⁴ Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.
• ¹⁵ Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
• ¹⁶ Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
• ¹⁷ Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
• ¹⁸ Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• ¹⁹ Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
• ²⁰ Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
• ²¹ Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
• ²² Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
• ²³ Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
• ²⁴ Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
• ²⁵ Department of Immunology, University of Toronto, Toronto, Ontario, Canada.
• ²⁶ Division of Cellular Polarity and Viral Infection, German Cancer Research Center (DKFZ), Heidelberg, Germany.
• ²⁷ Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
• ²⁸ Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
• ²⁹ Genome Opinion, Inc., Seoul, Republic of Korea.
• ³⁰ Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• ³¹ Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
• ³² Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
• ³³ Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
• ³⁴ Department of Medicine and Program in Mendelian Genetics, Weill Cornell Medicine, New York, NY, USA.
• ³⁵ Department of Medicine, Infectious Diseases Division, Howard University Hospital, Howard University College of Medicine, Washington, DC, USA.
• ³⁶ Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
• ³⁷ Division of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
• ³⁸ Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ³⁹ Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
• ⁴⁰ Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
• ⁴¹ Department of Biochemistry and Molecular Biology, National Human Genome Center, Howard University College of Medicine, Washington, DC, USA.
• ⁴² Veterans Affairs Medical Center, Washington, DC, USA.
• ⁴³ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
• ⁴⁴ Department of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• ⁴⁵ Department of Infectious Diseases, Virology, University Hospital Heidelberg, Heidelberg, Germany.
• ⁴⁶ Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. prokuninal@mail.nih.gov.