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Page 1
Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy.
Mol Cancer Ther. 2023 Jul 5;22(7):807-817. doi: 10.1158/1535-7163.MCT-22-0721.
Mol Cancer Ther. 2023.
PMID: 36939275
OATD-02 Validates the Benefits of Pharmacological Inhibition of Arginase 1 and 2 in Cancer.
Grzybowski MM, Stańczak PS, Pomper P, Błaszczyk R, Borek B, Gzik A, Nowicka J, Jędrzejczak K, Brzezińska J, Rejczak T, Güner-Chalimoniuk NC, Kikulska A, Mlącki M, Pęczkowicz-Szyszka J, Olczak J, Gołębiowski A, Dzwonek K, Dobrzański P, Zasłona Z.
Grzybowski MM, et al. Among authors: gzik a.
Cancers (Basel). 2022 Aug 17;14(16):3967. doi: 10.3390/cancers14163967.
Cancers (Basel). 2022.
PMID: 36010962
Free PMC article.
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Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma.
Czystowska-Kuzmicz M, Sosnowska A, Nowis D, Ramji K, Szajnik M, Chlebowska-Tuz J, Wolinska E, Gaj P, Grazul M, Pilch Z, Zerrouqi A, Graczyk-Jarzynka A, Soroczynska K, Cierniak S, Koktysz R, Elishaev E, Gruca S, Stefanowicz A, Blaszczyk R, Borek B, Gzik A, Whiteside T, Golab J.
Czystowska-Kuzmicz M, et al. Among authors: gzik a.
Nat Commun. 2019 Jul 5;10(1):3000. doi: 10.1038/s41467-019-10979-3.
Nat Commun. 2019.
PMID: 31278254
Free PMC article.
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Novel orally bioavailable piperidine derivatives as extracellular arginase inhibitors developed by a ring expansion.
Gzik A, Borek B, Chrzanowski J, Jedrzejczak K, Dziegielewski M, Brzezinska J, Nowicka J, Grzybowski MM, Rejczak T, Niedzialek D, Wieczorek G, Olczak J, Golebiowski A, Zaslona Z, Blaszczyk R.
Gzik A, et al.
Eur J Med Chem. 2024 Jan 15;264:116033. doi: 10.1016/j.ejmech.2023.116033. Epub 2023 Dec 10.
Eur J Med Chem. 2024.
PMID: 38096651
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Synthesis of chiral triazine coupling reagents based on esters of N-alkylproline and their application in the enantioselective incorporation of D or L amino acid residue directly from racemic substrate.
Kasperowicz-Frankowska K, Gzik A, Dziemidkiewicz M, Kolesińska B, Kamiński ZJ.
Kasperowicz-Frankowska K, et al. Among authors: gzik a.
Acta Pol Pharm. 2014 Nov-Dec;71(6):994-1003.
Acta Pol Pharm. 2014.
PMID: 25745772
Free article.
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