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Page 1
Enhanced pathogenicity of Th17 cells due to natalizumab treatment: Implications for MS disease rebound.
Janoschka C, Lindner M, Koppers N, Starost L, Liebmann M, Eschborn M, Schneider-Hohendorf T, Windener F, Schafflick D, Fleck AK, Koch K, Deffner M, Schwarze AS, Schulte-Mecklenbeck A, Metz I, Meuth SG, Gross CC, Meyer Zu Hörste G, Schwab N, Kuhlmann T, Wiendl H, Stoll M, Klotz L. Janoschka C, et al. Among authors: fleck ak. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2209944120. doi: 10.1073/pnas.2209944120. Epub 2022 Dec 27. Proc Natl Acad Sci U S A. 2023. PMID: 36574650 Free PMC article.
Single-cell profiling reveals preferential reduction of memory B cell subsets in cladribine patients that correlates with treatment response.
Teschner VE, Fleck AK, Walter C, Schwarze AS, Eschborn M, Wirth T, Steinberg OV, Schulte-Mecklenbeck A, Lu IN, Herrera-Rivero M, Janoschka C, Lünemann JD, Schwab N, Meyer Zu Hörste G, Varghese J, Gross CC, Pul R, Kleinschnitz C, Mader S, Meinl E, Stoll M, Wiendl H, Klotz L. Teschner VE, et al. Among authors: fleck ak. Ther Adv Neurol Disord. 2023 Dec 9;16:17562864231211077. doi: 10.1177/17562864231211077. eCollection 2023. Ther Adv Neurol Disord. 2023. PMID: 38084102 Free PMC article.
CNS Pericytes Modulate Local T Cell Infiltration in EAE.
Koch K, Lindner M, Fleck AK, Liebmann M, Eschborn M, Zondler L, Diéguez-Hurtado R, Adams RH, Meyer Zu Hörste G, Zarbock A, Kuhlmann T, Wiendl H, Klotz L. Koch K, et al. Among authors: fleck ak. Int J Mol Sci. 2022 Oct 28;23(21):13081. doi: 10.3390/ijms232113081. Int J Mol Sci. 2022. PMID: 36361868 Free PMC article.
Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity.
Fleck AK, Hucke S, Teipel F, Eschborn M, Janoschka C, Liebmann M, Wami H, Korn L, Pickert G, Hartwig M, Wirth T, Herold M, Koch K, Falk-Paulsen M, Dobrindt U, Kovac S, Gross CC, Rosenstiel P, Trautmann M, Wiendl H, Schuppan D, Kuhlmann T, Klotz L. Fleck AK, et al. Brain. 2021 May 7;144(4):1152-1166. doi: 10.1093/brain/awab040. Brain. 2021. PMID: 33899089 Free PMC article. Clinical Trial.
Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice.
Schiffmann D, Lampkemeyer V, Lindner M, Fleck AK, Koch K, Eschborn M, Liebmann M, Strecker JK, Minnerup J, Wiendl H, Klotz L. Schiffmann D, et al. Among authors: fleck ak. Int J Mol Sci. 2023 Oct 31;24(21):15798. doi: 10.3390/ijms242115798. Int J Mol Sci. 2023. PMID: 37958787 Free PMC article.
Activation of FXR pathway does not alter glial cell function.
Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T. Albrecht S, et al. Among authors: fleck ak. J Neuroinflammation. 2017 Mar 28;14(1):66. doi: 10.1186/s12974-017-0833-6. J Neuroinflammation. 2017. PMID: 28351411 Free PMC article.
The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion.
Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck AK, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L. Hucke S, et al. Among authors: fleck ak. Acta Neuropathol. 2016 Sep;132(3):413-31. doi: 10.1007/s00401-016-1593-6. Epub 2016 Jul 6. Acta Neuropathol. 2016. PMID: 27383204