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A glucotolerant β-glucosidase from the fungus Talaromyces amestolkiae and its conversion into a glycosynthase for glycosylation of phenolic compounds.
Méndez-Líter JA, Nieto-Domínguez M, Fernández de Toro B, González Santana A, Prieto A, Asensio JL, Cañada FJ, de Eugenio LI, Martínez MJ. Méndez-Líter JA, et al. Among authors: gonzalez santana a. Microb Cell Fact. 2020 Jun 10;19(1):127. doi: 10.1186/s12934-020-01386-1. Microb Cell Fact. 2020. PMID: 32522206 Free PMC article. Review.
Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study.
Prasch H, Wolfsgruber A, Thonhofer M, Culum A, Mandl C, Weber P, Zündel M, Nasseri SA, Gonzalez Santana A, Tegl G, Nidetzky B, Gruber K, Stütz AE, Withers SG, Wrodnigg TM. Prasch H, et al. Among authors: gonzalez santana a. Chembiochem. 2023 Dec 1;24(23):e202300480. doi: 10.1002/cbic.202300480. Epub 2023 Oct 10. Chembiochem. 2023. PMID: 37715738
C-5a-substituted validamine type glycosidase inhibitors.
Schalli M, Wolfsgruber A, Gonzalez Santana A, Tysoe C, Fischer R, Stütz AE, Thonhofer M, Withers SG. Schalli M, et al. Among authors: gonzalez santana a. Carbohydr Res. 2017 Feb 22;440-441:1-9. doi: 10.1016/j.carres.2017.01.006. Epub 2017 Jan 13. Carbohydr Res. 2017. PMID: 28135569
Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.
Weber P, Thonhofer M, Averill S, Davies GJ, Santana AG, Müller P, Nasseri SA, Offen WA, Pabst BM, Paschke E, Schalli M, Torvisco A, Tschernutter M, Tysoe C, Windischhofer W, Withers SG, Wolfsgruber A, Wrodnigg TM, Stütz AE. Weber P, et al. Among authors: santana ag. Molecules. 2020 Sep 3;25(17):4025. doi: 10.3390/molecules25174025. Molecules. 2020. PMID: 32899288 Free PMC article.
Transglycosylation products generated by Talaromyces amestolkiae GH3 β-glucosidases: effect of hydroxytyrosol, vanillin and its glucosides on breast cancer cells.
Méndez-Líter JA, Tundidor I, Nieto-Domínguez M, de Toro BF, González Santana A, de Eugenio LI, Prieto A, Asensio JL, Cañada FJ, Sánchez C, Martínez MJ. Méndez-Líter JA, et al. Among authors: gonzalez santana a. Microb Cell Fact. 2019 May 31;18(1):97. doi: 10.1186/s12934-019-1147-4. Microb Cell Fact. 2019. PMID: 31151435 Free PMC article.
Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.
Thonhofer M, Weber P, Gonzalez Santana A, Tysoe C, Fischer R, Pabst BM, Paschke E, Schalli M, Stütz AE, Tschernutter M, Windischhofer W, Withers SG. Thonhofer M, et al. Among authors: gonzalez santana a. Carbohydr Res. 2016 Jun 24;429:71-80. doi: 10.1016/j.carres.2016.03.020. Epub 2016 Mar 31. Carbohydr Res. 2016. PMID: 27063389
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-galactosidase inhibitors and low concentration activators of GM1-gangliosidosis-related human lysosomal β-galactosidase.
Thonhofer M, Weber P, Santana AG, Fischer R, Pabst BM, Paschke E, Schalli M, Stütz AE, Tschernutter M, Windischhofer W, Withers SG. Thonhofer M, et al. Among authors: santana ag. Bioorg Med Chem Lett. 2016 Mar 1;26(5):1438-42. doi: 10.1016/j.bmcl.2016.01.059. Epub 2016 Jan 22. Bioorg Med Chem Lett. 2016. PMID: 26838810