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Page 1
Selective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain.
Feldman HC, Merlini E, Guijas C, DeMeester KE, Njomen E, Kozina EM, Yokoyama M, Vinogradova E, Reardon HT, Melillo B, Schreiber SL, Loreto A, Blankman JL, Cravatt BF. Feldman HC, et al. Among authors: loreto a. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119. doi: 10.1073/pnas.2208457119. Epub 2022 Aug 22. Proc Natl Acad Sci U S A. 2022. PMID: 35994671 Free PMC article.
The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila.
Llobet Rosell A, Paglione M, Gilley J, Kocia M, Perillo G, Gasparrini M, Cialabrini L, Raffaelli N, Angeletti C, Orsomando G, Wu PH, Coleman MP, Loreto A, Neukomm LJ. Llobet Rosell A, et al. Among authors: loreto a. Elife. 2022 Dec 23;11:e80245. doi: 10.7554/eLife.80245. Elife. 2022. PMID: 36476387 Free PMC article.
SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.
Fazal SV, Mutschler C, Chen CZ, Turmaine M, Chen CY, Hsueh YP, Ibañez-Grau A, Loreto A, Casillas-Bajo A, Cabedo H, Franklin RJM, Barker RA, Monk KR, Steventon BJ, Coleman MP, Gomez-Sanchez JA, Arthur-Farraj P. Fazal SV, et al. Among authors: loreto a. Front Cell Neurosci. 2023 Apr 5;17:1158388. doi: 10.3389/fncel.2023.1158388. eCollection 2023. Front Cell Neurosci. 2023. PMID: 37091921 Free PMC article.
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Loreto A, Angeletti C, Gu W, Osborne A, Nieuwenhuis B, Gilley J, Merlini E, Arthur-Farraj P, Amici A, Luo Z, Hartley-Tassell L, Ve T, Desrochers LM, Wang Q, Kobe B, Orsomando G, Coleman MP. Loreto A, et al. Elife. 2021 Dec 6;10:e72823. doi: 10.7554/eLife.72823. Elife. 2021. PMID: 34870595 Free PMC article.
24 results