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Reevaluation of bromodomain ligands targeting BAZ2A.
Cazzanelli G, Vedove AD, Parolin E, D'Agostino VG, Unzue A, Nevado C, Caflisch A, Lolli G. Cazzanelli G, et al. Among authors: vedove ad. Protein Sci. 2023 Sep;32(9):e4752. doi: 10.1002/pro.4752. Protein Sci. 2023. PMID: 37574751 Free PMC article.
Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing.
Dalle Vedove A, Cazzanelli G, Batiste L, Marchand JR, Spiliotopoulos D, Corsi J, D'Agostino VG, Caflisch A, Lolli G. Dalle Vedove A, et al. ACS Med Chem Lett. 2022 Aug 3;13(9):1434-1443. doi: 10.1021/acsmedchemlett.2c00173. eCollection 2022 Sep 8. ACS Med Chem Lett. 2022. PMID: 36105334 Free PMC article.
Identification of a BAZ2A Bromodomain Hit Compound by Fragment Joining.
Dalle Vedove A, Cazzanelli G, Corsi J, Sedykh M, D'Agostino VG, Caflisch A, Lolli G. Dalle Vedove A, et al. ACS Bio Med Chem Au. 2021 Dec 15;1(1):5-10. doi: 10.1021/acsbiomedchemau.1c00016. Epub 2021 Jul 7. ACS Bio Med Chem Au. 2021. PMID: 36147311 Free PMC article.
Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N 6-Methyladenosine-Modified RNAs.
Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, Bonomo I, Poulentzas G, Rosatti EF, Cazzanelli G, Alunno L, Belli R, Peroni D, Dassi E, Murakami S, Jaffrey SR, Fragai M, Mancini I, Lolli G, Quattrone A, Provenzani A. Micaelli M, et al. Among authors: dalle vedove a. ACS Pharmacol Transl Sci. 2022 Sep 14;5(10):872-891. doi: 10.1021/acsptsci.2c00008. eCollection 2022 Oct 14. ACS Pharmacol Transl Sci. 2022. PMID: 36268123 Free PMC article.
Pliability in the m6A-Binding Region Extends Druggability of YTH Domains.
Cazzanelli G, Dalle Vedove A, Spagnolli G, Terruzzi L, Colasurdo E, Boldrini A, Patsilinakos A, Sturlese M, Grottesi A, Biasini E, Provenzani A, Quattrone A, Lolli G. Cazzanelli G, et al. Among authors: dalle vedove a. J Chem Inf Model. 2024 Mar 11;64(5):1682-1690. doi: 10.1021/acs.jcim.4c00051. Epub 2024 Feb 28. J Chem Inf Model. 2024. PMID: 38417111
A novel class of selective CK2 inhibitors targeting its open hinge conformation.
Dalle Vedove A, Zonta F, Zanforlin E, Demitri N, Ribaudo G, Cazzanelli G, Ongaro A, Sarno S, Zagotto G, Battistutta R, Ruzzene M, Lolli G. Dalle Vedove A, et al. Eur J Med Chem. 2020 Jun 1;195:112267. doi: 10.1016/j.ejmech.2020.112267. Epub 2020 Mar 25. Eur J Med Chem. 2020. PMID: 32283296
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