Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial

David Conen; Ekaterine Popova; Michael Ke Wang; Matthew T V Chan; Giovanni Landoni; Cara Reimer; Sadeesh K Srinathan; Juan P Cata; Sean R McLean; Juan Carlos Trujillo Reyes; Ascensión Martín Grande; Anna Gonzalez Tallada; Daniel I Sessler; Edith Fleischmann; Donna E Maziak; Barbara Kabon; Luca Voltolini; Laura Gutiérrez-Soriano; Vikas Tandon; Deborah DuMerton; Biniam Kidane; Ravi Rajaram; Yaron Shargall; John D Neary; Jennifer R Wells; William F McIntyre; Steffen Blum; Sandra N Ofori; Jessica Vincent; Lizhen Xu; Zhuoru Li; Jeff S Healey; Amit X Garg; P J Devereaux; COP-AF Investigators

doi:10.1016/j.ahj.2023.01.018

Rationale and design of the colchicine for the prevention of perioperative atrial fibrillation in patients undergoing major noncardiac thoracic surgery (COP-AF) trial

Am Heart J. 2023 May:259:87-96. doi: 10.1016/j.ahj.2023.01.018. Epub 2023 Feb 7.

Authors

David Conen¹, Ekaterine Popova², Michael Ke Wang³, Matthew T V Chan⁴, Giovanni Landoni⁵, Cara Reimer⁶, Sadeesh K Srinathan⁷, Juan P Cata⁸, Sean R McLean⁹, Juan Carlos Trujillo Reyes¹⁰, Ascensión Martín Grande¹¹, Anna Gonzalez Tallada¹², Daniel I Sessler¹³, Edith Fleischmann¹⁴, Donna E Maziak¹⁵, Barbara Kabon¹⁴, Luca Voltolini¹⁶, Laura Gutiérrez-Soriano¹⁷, Vikas Tandon¹⁸, Deborah DuMerton⁶, Biniam Kidane¹⁹, Ravi Rajaram²⁰, Yaron Shargall²¹, John D Neary¹⁸, Jennifer R Wells²², William F McIntyre³, Steffen Blum²³, Sandra N Ofori²⁴, Jessica Vincent²², Lizhen Xu²⁵, Zhuoru Li²², Jeff S Healey²⁵, Amit X Garg²⁶, P J Devereaux³; COP-AF Investigators

Collaborators

COP-AF Investigators:
Devereaux²⁷, Jessica Vincent²⁸, Michael Ke Wang²⁷, Jennifer R Wells²⁸, David Conen²⁷, P J Devereaux²⁷, Jeff S Healey²⁹, Giovanni Landoni⁵, William F McIntyre²⁷, Ekaterine Popova², Daniel I Sessler³⁰, Sadeesh K Srinathan³¹, Jessica Vincent²⁸, Michael Ke Wang²⁷, Jennifer R Wells²⁸, P J Devereaux²⁷, Mohammed Amir³², Shrikant I Bangdiwala³³, Matthias Bossard³⁴, Matthew T V Chan⁴, John W Eikelboom²⁹, Edith Fleischmann³⁵, Jeff S Healey²⁹, Sanjit S Jolly²⁷, Giovanni Landoni⁵, William F McIntyre²⁷, Felix Ramón Montes³⁶, Ekaterine Popova², Cara Reimer³⁷, Denis Schmartz³⁸, Daniel I Sessler³⁰, Sadeesh K Srinathan³¹, Jessica Vincent²⁸, Chew Yin Wang³⁹, Michael Ke Wang²⁷, Jennifer R Wells²⁸, William F McIntyre²⁷, Jesus Alvarez-Garcia⁴⁰, Giuliana Lo Bianco⁴¹, Steffen Blum⁴², Danielle de Sa Boasquevisque²⁹, Flavia K Borges²⁷, Helene Chiarella-Redfern⁴³, Aranzazu Gonzalez-Osuna⁴⁴, Jose M Guerra-Ramos⁴⁵, Maura Marcucci²⁷, Pascal B Meyre⁴⁶, Sandra N Ofori⁴⁷, Christopher Oleynick⁴³, Anna Ramos-Pachón⁴⁸, Hugh Traquair⁴⁹, Michael Ke Wang²⁷, L Brent Mitchell⁵⁰, George Wyse²⁸, Davy Cheng⁵¹, Finlay A McAlister⁵², George A Wells⁵³, Geethan Baskaran²⁸, Julia Gennaccaro²⁸, Rosemary Howe²⁸, Louise Mastrangelo²⁸, Shirley Pettit²⁸, Subana Shahbaz²⁸, Makayla Tosh²⁸, Jessica Vincent²⁸, Jennifer R Wells²⁸, Simona J Zucchetto²⁸, Shrikant I Bangdiwala³³, Laura Heenan²⁸, Shun Fu Lee²⁹, Zhuoru Li²⁸, Lizhen Xu²⁹, Mohammed Amir³², Matthias Bossard³⁴, Matthew T V Chan⁴, Edith Fleischmann³⁵, Giovanni Landoni⁵, Felix Ramón Montes³⁶, Ekaterine Popova², Denis Schmartz³⁸, Daniel I Sessler³⁰, Chew Yin Wang³⁹, Barbara Kabon³⁵, Edith Fleischmann³⁵, Christian Reiterer⁵⁴, Alexander Taschner⁵⁴, Katharina Horvath⁵⁴, Nikolas Adamowitsch⁵⁴, Oliver Zotti⁵⁴, Nicole Hantáková⁵⁴, Beatrix Hochreiter⁵⁴, Denis Schmartz³⁸, Isabelle Huybrechts⁵⁵, Serge Cappeliez⁵⁶, John D Neary⁴⁹, Yaron Shargall⁵⁷, Vikas Tandon⁴⁹, Christian Finley⁵⁸, John Agzarian⁵⁸, Waël Hanna⁵⁸, Muammar Abdulrahman⁵⁸, Kelly Lawrence⁵⁸, Krysten Gregus⁵⁸, Faraaz Quraishi⁵⁸, Spencer Wikkerink⁵⁸, Christine Wallace⁵⁸, Merissa Prine⁵⁸, Emily Gregus⁵⁸, Jacqueline Hare⁵⁸, Kristen Lombardo⁵⁸, Behashta Fezia⁵⁸, Teresa Columbus⁵⁸, Cara Reimer³⁷, Deborah DuMerton³⁷, Ken Reid³⁷, Joel Parlow³⁷, Wiley Chung³⁷, Maria Karizhenskaia³⁷, Aftab Malik³⁷, Sadeesh K Srinathan³¹, Biniam Kidane⁵⁹, Richard Liu⁶⁰, Lawrence Tan⁶⁰, Stephen Gowing⁶⁰, Gordon Buduhan⁶⁰, Stephanie Enns⁶⁰, Emma Poole⁶⁰, Kristin Graham⁶⁰, Sean R McLean⁶¹, Anna McGuire⁶², Jens Lohser⁶², Shirley Lim⁶², Rebecca Grey⁶², Kyle Grant⁶², Alex L Lee⁶², James J Choi⁶², Leith R Dewar⁶², John Yee⁶², Donna E Maziak⁶³, Andrew J E Seely⁶⁴, Sebastien Gilbert⁶⁴, P James Villeneuve⁶⁴, Sudhir Sundaresan⁶⁴, Susan D Moffatt-Bruce⁶⁴, Molly Gingrich⁶⁴, Anna Fazekas⁶⁴, Kirby Bucciero⁶⁴, Richard A Malthaner⁶⁵, Deb Lewis⁶⁵, Dalilah Fortin⁶⁵, Mehdi Qiabi⁶⁵, Rahul Nayak⁶⁵, Madelaine Marie Plourde⁶⁶, Daniel Sellers⁶⁷, Laura Donahoe⁶⁷, Marco Lefebvre⁶⁸, Luc Lanthier⁶⁸, Colin Schieman⁶⁹, Amal Bessissow⁷⁰, Matthew T V Chan⁴, Gavin M Joynt⁴, Randolph H L Wong⁴, Rainbow W H Lau⁴, Wai Tat Wong⁴, Gordon Y S Choi⁴, Eva Lee⁴, Ka Yan Hui⁴, Beaker Fung⁴, Chee Sam Chan⁴, Laura Gutiérrez-Soriano³⁶, Felix Ramón Montes³⁶, Laura Carmenza Castañeda⁷¹, Luis Jaime Téllez⁷¹, Lina Marcela Ortiz-Ramirez⁷¹, Giovanni Landoni⁵, Simona De Santis⁷², Giovanni Favaro⁷², Piergiorgio Muriana⁷², Cristina Nakhnoukh⁷², Pierluigi Novellis⁷², Stefano Turi⁷², Giulia Veronesi⁷², Matteo Angelini⁷², Luca Voltolini¹⁶, Stefano Bongiolatti⁷³, Alberto Salvicchi⁷³, Lavinia Gatteschi⁷³, Rossella Indino⁷³, Simone Tombelli⁷³, Alice Ravasin⁷³, Ottavia Salimbene⁷³, Giulio Luca Rosboch⁷⁴, Eleonora Balzani⁷⁴, Domenico Massullo⁷⁵, Silvia Fiorelli⁷⁵, Francesco Londero⁷⁶, William Grossi⁷⁶, Chew Yin Wang³⁹, Tyng Yan Ng³⁹, Woan Shiang See⁷⁷, Mohammed Amir³², Mohammed Asghar Nawaz⁷⁸, Juan Carlos Trujillo Reyes¹⁰, Ekaterine Popova², Elisabeth Martinez Tellez⁷⁹, Josep Belda Sanchis⁷⁹, Georgina Planas Cánovas⁷⁹, Ana Parera Ruiz⁷⁹, Esther Cladellas Gutierrez⁷⁹, Mauro Guarino⁷⁹, Gerard Urrutia Cuchi⁷⁹, Marta Argilaga Nogues⁷⁹, Anna Rovira Juan⁷⁹, Jose M Guerra-Ramos⁴⁵, Jesus Alvarez-Garcia⁴⁰, Aranzazu Gonzalez-Osuna⁴⁴, Melixa Medina-Aedo⁷⁹, Ascensión Martín Grande¹¹, Diego Parise Roux¹¹, Luis Gajate Martín¹¹, Angélica De Pablo Pajares¹¹, Angel Manuel Candela Toha¹¹, Nicolás Moreno Mata¹¹, Gema Muñoz Molina¹¹, Usue Caballero Silva¹¹, Alberto Cabañero¹¹, Sara Fra Fernandez¹¹, Anna Gonzàlez Tallada¹², Susana González Suarez⁸⁰, Montserrat Ribas Ball⁸⁰, Miriam De Nadal Clanchet⁸⁰, Laura Ruiz-Villa⁸¹, M M Martí-Ejarque⁸¹, Mireia Gili-Bueno⁸¹, Jorge Hernández Ferrández⁸¹, Neus Pons Llobet⁸¹, Patricia Cruz⁸², Guillermo Sánchez-Pedrosa⁸², Patricia Duque⁸², Leire Azcárate⁸², Lorena Martín-Albo⁸², Alberto Rodríguez-Fuster⁸³, Silvia Bermejo-Martínez⁸³, Albert Carramiñana⁸⁴, Matthias Bossard³⁴, Fabrizio Minervini³⁴, Juan P Cata⁸⁵, Ravi Rajaram⁸⁶, German Corrales⁸⁷, Juan Jose Guerra-Londono⁸⁷, Reza Mehran⁸⁷, Boris Sepesi⁸⁷, Garrett Walsh⁸⁷, Daniel S Cukierman⁸⁷, Bryan E Marchant⁸⁸, Lynne C Harris⁸⁸, Bruce D Cusson⁸⁸, Scott A Miller⁸⁸, Steven C Minear⁸⁹, Camila Teixeira⁸⁹, Mario Pimentel⁸⁹, Andrew M Popoff⁹⁰, Wing Lee Cheung⁹⁰, Kelly Marsack⁹⁰, Sabry Ayad⁹¹, Jorge Araujo⁹¹, Tzonghuei H Chen⁹², Michael Essandoh⁹³, Jeremy S Poppers⁹⁴

Affiliations

¹ Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. Electronic address: David.conen@phri.ca.
² Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Iberoamerican Cochrane Centre, Barcelona, Spain.
³ Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
⁴ The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China.
⁵ Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
⁶ Kingston Health Sciences Centre, Kingston, Ontario, Canada.
⁷ Department of Surgery, University of Manitoba, Winnipeg, Manitoba , Canada.
⁸ Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
⁹ Department of Anesthesia, Vancouver Acute (Vancouver General Hospital and UBC Hospital), The University of British Columbia, Vancouver, British Columbia, Canada; Department of Anesthesia, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada.
¹⁰ Department of Thoracic Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
¹¹ Hospital Universitario Ramón y Cajal, Madrid, Spain.
¹² Department of Anesthesiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
¹³ Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH.
¹⁴ Department of Anesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
¹⁵ University of Ottawa, Ottawa, Ontario, Canada.
¹⁶ Thoracic Surgery Unit, Careggi University Hospital, Florence, Italy.
¹⁷ Department of Anesthesiology, Fundación CardioInfantil - Instituto de Cardiología, Bogotá, Colombia.
¹⁸ Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
¹⁹ Departments of Surgery, Physiology and Pathophysiology, University of Manitoba, Winnipeg, Manitoba, Canada.
²⁰ Department of Cardiothoracic Surgery, The University of Texas - MD Anderson Cancer Center, Houston, TX.
²¹ Division of Thoracic Surgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
²² Population Health Research Institute, Hamilton, Ontario, Canada.
²³ Population Health Research Institute, Hamilton, Ontario, Canada; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
²⁴ Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada; University of Port Harcourt, Choba, Nigeria.
²⁵ Population Health Research Institute, Hamilton, Ontario, Canada; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
²⁶ Population Health Research Institute, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada; Departments of Medicine, Epidemiology and Biostatistics, Western University, London, Ontario, Canada.
²⁷ Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
²⁸ Population Health Research Institute, Hamilton, ON, Canada.
²⁹ Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
³⁰ Department of Outcomes Research, Anesthesiology Institute, Cleveland Clinic, Cleveland, OH, United States.
³¹ Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.
³² Department of Surgery, Shifa International Hospital, Islamabad, Pakistan; Department of Surgery, Shifa Tameer-e-Millat University, Islamabad, Pakistan.
³³ Population Health Research Institute, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
³⁴ Luzerner Kantonsspital, Luzern, Switzerland.
³⁵ Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Vienna, Austria.
³⁶ Department of Anesthesiology, Fundación Cardioinfantil - Instituto de Cardiología, Bogotá, Colombia.
³⁷ Kingston Health Sciences Centre, Kingston, ON, Canada.
³⁸ H.U.B - Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
³⁹ Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
⁴⁰ Department of Cardiology, Hospital Universitario Ramón y Cajal, Madrid, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain.
⁴¹ Università Vita-Salute San Raffaele, Milan, Italy.
⁴² Population Health Research Institute, Hamilton, ON, Canada; Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland.
⁴³ Division of General Internal Medicine, Department of Medicine, University of Calgary, Calgary, AB, Canada.
⁴⁴ Orthopedic Surgery and Traumatology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
⁴⁵ Biomedical Research Institute (IIB Sant Pau), Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares, Madrid, Spain; Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain.
⁴⁶ Cardiovascular Research Institute Basel, University Hospital Basel, Basel, Switzerland; Division of Cardiology, Department of Medicine, University Hospital Basel, Basel, Switzerland.
⁴⁷ Population Health Research Institute, Hamilton, ON, Canada; Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; University of Port Harcourt, Choba, Nigeria.
⁴⁸ Stroke Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
⁴⁹ Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
⁵⁰ Department of Cardiac Sciences, Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
⁵¹ School of Medicine, The Chinese University of Hong Kong (Shenzhen), Shenzhen, China.
⁵² Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
⁵³ Cardiovascular Research Methods Centre, Faculty of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
⁵⁴ Medical University of Vienna, Vienna, Austria.
⁵⁵ CUB Hôpital Erasme, Université libre de Bruxelles, Brussels, Belgium.
⁵⁶ University Hospital of Charleroi, Charleroi, Belgium.
⁵⁷ Division of Thoracic Surgery, Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
⁵⁸ St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
⁵⁹ Departments of Surgery, Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada.
⁶⁰ Health Sciences Centre, Winnipeg, Winnipeg, MB, Canada.
⁶¹ Department of Anesthesia, Vancouver Acute (Vancouver General Hospital and UBC Hospital), The University of British Columbia, Vancouver, BC, Canada; Department of Anesthesia, Pharmacology and Therapeutics, The University of British Columbia, Vancouver, BC, Canada.
⁶² Vancouver General Hospital, Vancouver, BC, Canada.
⁶³ University of Ottawa, Ottawa, ON, Canada.
⁶⁴ The Ottawa Hospital, Ottawa, ON, Canada.
⁶⁵ London Health Sciences Centre, London, ON, Canada.
⁶⁶ Victoria General Hospital, Halifax, NS, Canada.
⁶⁷ Toronto General Hospital, Toronto, ON, Canada.
⁶⁸ CIUSSS de l'Estrie - CHUS, Sherbrooke, QC, Canada.
⁶⁹ FFoothills Medical Centre, Calgary, AB, Canada.
⁷⁰ Montreal General Hospital, Montreal, QC, Canada.
⁷¹ Fundación Cardioinfantil - Instituto de Cardiología, Bogotá, Colombia.
⁷² IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁷³ Careggi University Hospital, Florence, Italy.
⁷⁴ A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
⁷⁵ Sant'Andrea Hospital, Rome, Italy.
⁷⁶ S. Maria della Misericordia University Hospital, Udine, Italy.
⁷⁷ Serdang Hospital, Kajang, Malaysia.
⁷⁸ Shifa International Hospital, Islamabad, Pakistan.
⁷⁹ Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
⁸⁰ Hospital Universitari Vall d'Hebron, Barcelona, Spain.
⁸¹ Hospital Universitari Sagrat Cor, Grupo Quironsalud, Barcelona, Spain.
⁸² Hospital Universitary Gregorio Marañon, Madrid, Spain.
⁸³ Hospital del Mar, Barcelona, Spain.
⁸⁴ Hospital Clínic, Barcelona, Barcelona, Spain.
⁸⁵ Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁸⁶ Department of Cardiothoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁸⁷ The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
⁸⁸ Atrium Health Wake Forest Baptist, Winston-Salem, NC, United States.
⁸⁹ Cleveland Clinic Florida, Weston, FL, United States.
⁹⁰ Henry Ford Health, Detroit, MI, United States.
⁹¹ Fairview Hospital, Cleveland Clinic, Cleveland, OH, United States.
⁹² Rhode Island Hospital, Providence, RI, United States.
⁹³ The Ohio State University Wexner Medical Center, Columbus, OH, United States.
⁹⁴ Stony Brook University Hospital, Stony Brook, NY, United States.

PMID: 36754105
DOI: 10.1016/j.ahj.2023.01.018

Abstract

Background: Perioperative atrial fibrillation (AF) and myocardial injury after noncardiac surgery (MINS) are common complications after noncardiac surgery. Inflammation has been implicated in the pathogenesis of both disorders. The COP-AF trial tests the hypothesis that colchicine reduces the incidence of perioperative AF and MINS in patients undergoing major noncardiac thoracic surgery.

Methods and results: The 'COlchicine for the Prevention of Perioperative Atrial Fibrillation' (COP-AF) trial is an international, blinded, randomized trial that compares colchicine to placebo in patients aged at least 55 years and undergoing major noncardiac thoracic surgery with general anesthesia. Exclusion criteria include a history of AF and a contraindication to colchicine (eg, severe renal dysfunction). Oral colchicine at a dose of 0.5 mg or matching placebo is given within 4 hours before surgery. Thereafter, patients receive colchicine 0.5 mg or placebo twice daily for a total of 10 days. The 2 independent co-primary outcomes are clinically important perioperative AF (including atrial flutter) and MINS during 14 days of follow-up. The main safety outcomes are sepsis or infection and non-infectious diarrhea. We aim to enroll 3,200 patients from approximately 40 sites across 11 countries to have at least 80% power for the independent evaluation of the 2 co-primary outcomes. The COP-AF main results are expected in 2023.

Conclusions: COP-AF is a large randomized and blinded trial designed to determine whether colchicine reduces the risk of perioperative AF or MINS in patients who have major noncardiac thoracic surgery.

Keywords: Atrial fibrillation; Colchicine; Inflammation; Myocardial injury; Prevention; Thoracic surgery.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Atrial Fibrillation* / complications
Atrial Fibrillation* / prevention & control
Colchicine / therapeutic use
Humans
Incidence
Postoperative Complications / drug therapy
Postoperative Complications / epidemiology
Postoperative Complications / prevention & control
Thoracic Surgery*

Substances

Colchicine

Abstract

Publication types

MeSH terms

Substances

Grants and funding