One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool

Fabrizio Politano; Ana K Gran-Magano; Nicholas E Leadbeater

doi:10.3390/molecules24203639

One-Pot Two-Step Synthesis of 2-Aryl benzimidazole N-oxides Using Microwave Heating as a Tool

Molecules. 2019 Oct 9;24(20):3639. doi: 10.3390/molecules24203639.

Authors

Fabrizio Politano¹, Ana K Gran-Magano², Nicholas E Leadbeater³

Affiliations

¹ Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269-3060, USA. fabrizio.politano@uconn.edu.
² Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269-3060, USA. ana.magano@uconn.edu.
³ Department of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, CT 06269-3060, USA. nicholas.leadbeater@uconn.edu.

Abstract

A methodology is reported for the preparation of 2-aryl-benzimidazole-3-oxide derivatives. By means of a one-pot two-step protocol, a library of 42 new compounds has been prepared. Reactions were performed in a total time of 40 min using microwave heating as a tool. A streamlined work-up process was also developed, allowing for facile isolation of the products. The methodology offers a more sustainable approach than previous routes, with only water and ethanol being used as solvents, and the products being isolated by means of a simple filtration without the need for any further purification.

Keywords: benzimidazole; benzimidazole N-oxide; green chemistry; microwave heating.

MeSH terms

Benzimidazoles / chemical synthesis
Benzimidazoles / chemistry*
Chemistry Techniques, Synthetic*
Green Chemistry Technology*
Heating*
Microwaves*
Molecular Structure
Oxides / chemistry*

Substances

Benzimidazoles
Oxides

Abstract

MeSH terms

Substances

Grants and funding