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Page 1
Indoleamine and tryptophan 2,3-dioxygenases as important future therapeutic targets.
Pharmacol Ther. 2021 May;221:107746. doi: 10.1016/j.pharmthera.2020.107746. Epub 2020 Nov 16.
Pharmacol Ther. 2021.
PMID: 33212094
Review.
Novel Selective IDO1 Inhibitors with Isoxazolo[5,4-d]pyrimidin-4(5H)-one Scaffold.
Dolšak A, Bratkovič T, Mlinarič L, Ogorevc E, Švajger U, Gobec S, Sova M.
Dolšak A, et al.
Pharmaceuticals (Basel). 2021 Mar 15;14(3):265. doi: 10.3390/ph14030265.
Pharmaceuticals (Basel). 2021.
PMID: 33804161
Free PMC article.
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Covalent inhibitors of bacterial peptidoglycan biosynthesis enzyme MurA with chloroacetamide warhead.
Grabrijan K, Hrast M, Proj M, Dolšak A, Zdovc I, Imre T, Petri L, Ábrányi-Balogh P, Keserű GM, Gobec S.
Grabrijan K, et al. Among authors: dolsak a.
Eur J Med Chem. 2022 Dec 5;243:114752. doi: 10.1016/j.ejmech.2022.114752. Epub 2022 Sep 13.
Eur J Med Chem. 2022.
PMID: 36126388
Free article.
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Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B.
Knez D, Colettis N, Iacovino LG, Sova M, Pišlar A, Konc J, Lešnik S, Higgs J, Kamecki F, Mangialavori I, Dolšak A, Žakelj S, Trontelj J, Kos J, Binda C, Marder M, Gobec S.
Knez D, et al. Among authors: dolsak a.
J Med Chem. 2020 Feb 13;63(3):1361-1387. doi: 10.1021/acs.jmedchem.9b01886. Epub 2020 Jan 22.
J Med Chem. 2020.
PMID: 31917923
Free PMC article.
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Further hit optimization of 6-(trifluoromethyl)pyrimidin-2-amine based TLR8 modulators: Synthesis, biological evaluation and structure-activity relationships.
Dolšak A, Šribar D, Scheffler A, Grabowski M, Švajger U, Gobec S, Holze J, Weindl G, Wolber G, Sova M.
Dolšak A, et al.
Eur J Med Chem. 2021 Dec 5;225:113809. doi: 10.1016/j.ejmech.2021.113809. Epub 2021 Aug 28.
Eur J Med Chem. 2021.
PMID: 34488023
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Structural Optimization and Biological Evaluation of Isoxazolo[5,4-d]pyrimidines as Selective Toll-Like Receptor 7 Agonists.
Strašek Benedik N, Dolšak A, Švajger U, Sosič I, Gobec S, Sova M.
Strašek Benedik N, et al. Among authors: dolsak a.
ACS Omega. 2024 Jan 4;9(2):2362-2382. doi: 10.1021/acsomega.3c06343. eCollection 2024 Jan 16.
ACS Omega. 2024.
PMID: 38250345
Free PMC article.
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Selective Toll-like receptor 7 agonists with novel chromeno[3,4-d]imidazol-4(1H)-one and 2-(trifluoromethyl)quinoline/ quinazoline-4-amine scaffolds.
Dolšak A, Švajger U, Lešnik S, Konc J, Gobec S, Sova M.
Dolšak A, et al.
Eur J Med Chem. 2019 Oct 1;179:109-122. doi: 10.1016/j.ejmech.2019.06.030. Epub 2019 Jun 18.
Eur J Med Chem. 2019.
PMID: 31247373
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