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Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.
So JY, Wahler JE, Yoon T, Smolarek AK, Lin Y, Shih WJ, Maehr H, Uskokovic M, Liby KT, Sporn MB, Suh N. So JY, et al. Among authors: smolarek ak. Cancer Prev Res (Phila). 2013 Sep;6(9):959-70. doi: 10.1158/1940-6207.CAPR-13-0087. Epub 2013 Jul 15. Cancer Prev Res (Phila). 2013. PMID: 23856074 Free PMC article.
Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia.
Smolarek AK, So JY, Thomas PE, Lee HJ, Paul S, Dombrowski A, Wang CX, Saw CL, Khor TO, Kong AN, Reuhl K, Lee MJ, Yang CS, Suh N. Smolarek AK, et al. Mol Carcinog. 2013 Jul;52(7):514-25. doi: 10.1002/mc.21886. Epub 2012 Mar 2. Mol Carcinog. 2013. PMID: 22389237 Free PMC article.
Combination of atorvastatin with sulindac or naproxen profoundly inhibits colonic adenocarcinomas by suppressing the p65/β-catenin/cyclin D1 signaling pathway in rats.
Suh N, Reddy BS, DeCastro A, Paul S, Lee HJ, Smolarek AK, So JY, Simi B, Wang CX, Janakiram NB, Steele V, Rao CV. Suh N, et al. Among authors: smolarek ak. Cancer Prev Res (Phila). 2011 Nov;4(11):1895-902. doi: 10.1158/1940-6207.CAPR-11-0222. Epub 2011 Jul 15. Cancer Prev Res (Phila). 2011. PMID: 21764859 Free PMC article.