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Demonstrating Tumor Vascular Disrupting Activity of the Small-Molecule Dihydronaphthalene Tubulin-Binding Agent OXi6196 as a Potential Therapeutic for Cancer Treatment.
Liu L, Schuetze R, Gerberich JL, Lopez R, Odutola SO, Tanpure RP, Charlton-Sevcik AK, Tidmore JK, Taylor EA, Kapur P, Hammers H, Trawick ML, Pinney KG, Mason RP. Liu L, et al. Among authors: charlton sevcik ak. Cancers (Basel). 2022 Aug 30;14(17):4208. doi: 10.3390/cancers14174208. Cancers (Basel). 2022. PMID: 36077745 Free PMC article.
Imaging-Guided Evaluation of the Novel Small-Molecule Benzosuberene Tubulin-Binding Agent KGP265 as a Potential Therapeutic Agent for Cancer Treatment.
Guo Y, Wang H, Gerberich JL, Odutola SO, Charlton-Sevcik AK, Li M, Tanpure RP, Tidmore JK, Trawick ML, Pinney KG, Mason RP, Liu L. Guo Y, et al. Among authors: charlton sevcik ak. Cancers (Basel). 2021 Sep 24;13(19):4769. doi: 10.3390/cancers13194769. Cancers (Basel). 2021. PMID: 34638255 Free PMC article.
Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.
Kishore Kumar GD, Chavarria GE, Charlton-Sevcik AK, Arispe WM, Macdonough MT, Strecker TE, Chen SE, Siim BG, Chaplin DJ, Trawick ML, Pinney KG. Kishore Kumar GD, et al. Among authors: charlton sevcik ak. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. doi: 10.1016/j.bmcl.2009.12.090. Epub 2010 Jan 6. Bioorg Med Chem Lett. 2010. PMID: 20089402 Free PMC article.
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.
Parker EN, Song J, Kishore Kumar GD, Odutola SO, Chavarria GE, Charlton-Sevcik AK, Strecker TE, Barnes AL, Sudhan DR, Wittenborn TR, Siemann DW, Horsman MR, Chaplin DJ, Trawick ML, Pinney KG. Parker EN, et al. Among authors: charlton sevcik ak. Bioorg Med Chem. 2015 Nov 1;23(21):6974-92. doi: 10.1016/j.bmc.2015.09.036. Epub 2015 Sep 25. Bioorg Med Chem. 2015. PMID: 26462052 Free PMC article.
The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.
Strecker TE, Odutola SO, Lopez R, Cooper MS, Tidmore JK, Charlton-Sevcik AK, Li L, MacDonough MT, Hadimani MB, Ghatak A, Liu L, Chaplin DJ, Mason RP, Pinney KG, Trawick ML. Strecker TE, et al. Among authors: charlton sevcik ak. Cancer Lett. 2015 Dec 1;369(1):229-41. doi: 10.1016/j.canlet.2015.08.021. Epub 2015 Sep 1. Cancer Lett. 2015. PMID: 26325604 Free PMC article.