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Targeting the Blood-Brain Barrier to Prevent Sepsis-Associated Cognitive Impairment.
Nwafor DC, Brichacek AL, Mohammad AS, Griffith J, Lucke-Wold BP, Benkovic SA, Geldenhuys WJ, Lockman PR, Brown CM. Nwafor DC, et al. Among authors: brichacek al. J Cent Nerv Syst Dis. 2019 Apr 9;11:1179573519840652. doi: 10.1177/1179573519840652. eCollection 2019. J Cent Nerv Syst Dis. 2019. PMID: 31007531 Free PMC article. Review.
Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.
Nwafor DC, Chakraborty S, Brichacek AL, Jun S, Gambill CA, Wang W, Engler-Chiurazzi EB, Dakhlallah D, Pinkerton AB, Millán JL, Benkovic SA, Brown CM. Nwafor DC, et al. Among authors: brichacek al. Brain Behav Immun. 2020 Feb;84:115-131. doi: 10.1016/j.bbi.2019.11.016. Epub 2019 Nov 25. Brain Behav Immun. 2020. PMID: 31778743 Free PMC article.