Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles

Agnieszka Czylkowska; Bartłomiej Rogalewicz; Małgorzata Szczesio; Anita Raducka; Katarzyna Gobis; Paweł Szymański; Kamila Czarnecka; Bruno Cury Camargo; Jacek Szczytko; Alexey Babich; Sergey Dubkov; Petr Lazarenko

doi:10.3390/ijms23062980

Antitumor Activity against A549 Cancer Cells of Three Novel Complexes Supported by Coating with Silver Nanoparticles

Int J Mol Sci. 2022 Mar 10;23(6):2980. doi: 10.3390/ijms23062980.

Authors

Affiliations

¹ Institute of General and Ecological Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
² Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Gen. Hallera 107, 80-416 Gdansk, Poland.
³ Department of Pharmaceutical Chemistry, Drug Analyses and Radiopharmacy, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
⁴ Department of Radiobiology and Radiation Protection, Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, Poland.
⁵ Institute of Experimental Physics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093 Warszawa, Poland.
⁶ Institute of Advanced Materials and Technologies, National Research University of Electronic Technology, Bld. 1, Shokin Square, Zelenograd, 124498 Moscow, Russia.

Abstract

A novel biologically active organic ligand L (N'-benzylidenepyrazine-2-carbohydrazonamide) and its three coordination compounds have been synthesized and structurally described. Their physicochemical and biological properties have been thoroughly studied. Cu(II), Zn(II), and Cd(II) complexes have been analyzed by F-AAS spectrometry and elemental analysis. The way of metal-ligand coordination was discussed based on FTIR spectroscopy and UV-VIS-NIR spectrophotometry. The thermal behavior of investigated compounds was studied in the temperature range 25-800 °C. All compounds are stable at room temperature. The complexes decompose in several stages. Magnetic studies revealed strong antiferromagnetic interaction. Their cytotoxic activity against A549 lung cancer cells have been studied with promising results. We have also investigated the biological effect of coating studied complexes with silver nanoparticles. The morphology of the surface was studied using SEM imaging.

Keywords: A549 lung cancer cells; FTIR spectroscopy; TG-DTG analysis; UV-VIS-NIR spectrophotometry; antitumor activity; coordination compound; magnetization measurements.

MeSH terms

Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Coordination Complexes* / chemistry
Coordination Complexes* / pharmacology
Ligands
Metal Nanoparticles*
Neoplasms*
Silver / pharmacology

Substances

Antineoplastic Agents
Coordination Complexes
Ligands
Silver