N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Abakir A, Giles TC, Cristini A, Foster JM, Dai N, Starczak M, Rubio-Roldan A, Li M, Eleftheriou M, Crutchley J, Flatt L, Young L, Gaffney DJ, Denning C, Dalhus B, Emes RD, Gackowski D, Corrêa IR Jr, Garcia-Perez JL, Klungland A, Gromak N, Ruzov A.
Abakir A, et al.
Nat Genet. 2020 Jan;52(1):48-55. doi: 10.1038/s41588-019-0549-x. Epub 2019 Dec 16.
Nat Genet. 2020.
PMID: 31844323
Free PMC article.
We demonstrate that m(6)A-containing R-loops accumulate during G(2)/M and are depleted at G(0)/G(1) phases of the cell cycle, and that the m(6)A reader promoting mRNA degradation, YTHDF2 (ref. (7)), interacts with R-loop-enriched loci in dividing cells. Conse …
We demonstrate that m(6)A-containing R-loops accumulate during G(2)/M and are depleted at G(0)/G(1) phases of the cell cycle, …