An Outbreak of a Respiratory Disorder at a Russian Swine Farm Associated with the Co-Circulation of PRRSV1 and PRRSV2

Viruses. 2020 Oct 15;12(10):1169. doi: 10.3390/v12101169.

Abstract

We conducted a cross-sectional study to identify the major respiratory pathogen responsible for an outbreak of respiratory disease at a swine farm in West Siberia in 2019. We discovered that the peak of morbidity and mortality coincided with a high level of porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2-related viremia. Based on longer PRRSV2 viremia, the dominant role of PRRSV2 over PRRSV1 in the outbreak was assumed. Phylogenetic analysis revealed that the PRRSV1 strain belonged to sub-genotype 2-one of the predominant groups of genotype 1 PRRSVs in Russia. A partial open reading frame 7 sequence of the PRRSV2 isolate demonstrated a high identity with modified live vaccine-related strains from Denmark (93%) and wild-type VR2332 (92%). We identified the first instance of PRRSV1/PRRSV2 mixed infection in Russia. This finding indicates that further field investigations are needed to access PRRSV2 epidemiology in eastern Europe.

Keywords: ORF7; PCV2; PRRSV1; PRRSV2; antibody detection; cross-sectional; phylogenetic analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Cross-Sectional Studies
  • Disease Outbreaks / veterinary*
  • Farms
  • Genetic Variation
  • Genotype
  • Open Reading Frames
  • Phylogeny
  • Porcine Reproductive and Respiratory Syndrome / epidemiology*
  • Porcine Reproductive and Respiratory Syndrome / mortality
  • Porcine Reproductive and Respiratory Syndrome / virology
  • Porcine respiratory and reproductive syndrome virus / classification
  • Porcine respiratory and reproductive syndrome virus / pathogenicity*
  • Siberia / epidemiology
  • Swine / virology

Substances

  • Antibodies, Viral