Alexandra L. Zakharenko - Search Results

Year	Number of Results
2011	1
2012	1
2013	1
2016	1
2017	2
2018	4
2019	4
2020	4
2021	6
2022	3
2023	5
2024	3

1

Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.

Zakharenko AL, Luzina OA, Chepanova AA, Dyrkheeva NS, Salakhutdinov NF, Lavrik OI. Zakharenko AL, et al. Int J Mol Sci. 2023 Mar 17;24(6):5781. doi: 10.3390/ijms24065781. Int J Mol Sci. 2023. PMID: 36982848 Free PMC article. Review.

2

Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties.

Ivankin DI, Kornienko TE, Mikhailova MA, Dyrkheeva NS, Zakharenko AL, Achara C, Reynisson J, Golyshev VM, Luzina OA, Volcho KP, Salakhutdinov NF, Lavrik OI. Ivankin DI, et al. Among authors: zakharenko al. Int J Mol Sci. 2023 Feb 14;24(4):3834. doi: 10.3390/ijms24043834. Int J Mol Sci. 2023. PMID: 36835244 Free PMC article.

3

Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.

Ivankin DI, Dyrkheeva NS, Zakharenko AL, Ilina ES, Zarkov TO, Reynisson J, Luzina OA, Volcho KP, Salakhutdinov NF, Lavrik OI. Ivankin DI, et al. Among authors: zakharenko al. Bioorg Med Chem Lett. 2022 Oct 1;73:128909. doi: 10.1016/j.bmcl.2022.128909. Epub 2022 Jul 27. Bioorg Med Chem Lett. 2022. PMID: 35907608

4

Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan.

Munkuev AA, Dyrkheeva NS, Kornienko TE, Ilina ES, Ivankin DI, Suslov EV, Korchagina DV, Gatilov YV, Zakharenko AL, Malakhova AA, Reynisson J, Volcho KP, Salakhutdinov NF, Lavrik OI. Munkuev AA, et al. Among authors: zakharenko al. Molecules. 2022 May 24;27(11):3374. doi: 10.3390/molecules27113374. Molecules. 2022. PMID: 35684313 Free PMC article.

5

New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.

Khomenko TM, Zakharenko AL, Kornienko TE, Chepanova AA, Dyrkheeva NS, Artemova AO, Korchagina DV, Achara C, Curtis A, Reynisson J, Volcho KP, Salakhutdinov NF, Lavrik OI. Khomenko TM, et al. Among authors: zakharenko al. Int J Mol Sci. 2023 May 23;24(11):9155. doi: 10.3390/ijms24119155. Int J Mol Sci. 2023. PMID: 37298106 Free PMC article.

6

Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides.

Zakharenko AL, Drenichev MS, Dyrkheeva NS, Ivanov GA, Oslovsky VE, Ilina ES, Chernyshova IA, Lavrik OI, Mikhailov SN. Zakharenko AL, et al. Molecules. 2020 Aug 13;25(16):3694. doi: 10.3390/molecules25163694. Molecules. 2020. PMID: 32823658 Free PMC article.

7

Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.

Ponomarev KY, Suslov EV, Zakharenko AL, Zakharova OD, Rogachev AD, Korchagina DV, Zafar A, Reynisson J, Nefedov AA, Volcho KP, Salakhutdinov NF, Lavrik OI. Ponomarev KY, et al. Among authors: zakharenko al. Bioorg Chem. 2018 Feb;76:392-399. doi: 10.1016/j.bioorg.2017.12.005. Epub 2017 Dec 9. Bioorg Chem. 2018. PMID: 29248742

8

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.

Filimonov AS, Chepanova AA, Luzina OA, Zakharenko AL, Zakharova OD, Ilina ES, Dyrkheeva NS, Kuprushkin MS, Kolotaev AV, Khachatryan DS, Patel J, Leung IKH, Chand R, Ayine-Tora DM, Reynisson J, Volcho KP, Salakhutdinov NF, Lavrik OI. Filimonov AS, et al. Among authors: zakharenko al. Molecules. 2019 Oct 15;24(20):3711. doi: 10.3390/molecules24203711. Molecules. 2019. PMID: 31619021 Free PMC article.

9

Usnic Acid Derivatives Inhibit DNA Repair Enzymes Tyrosyl-DNA Phosphodiesterases 1 and 2 and Act as Potential Anticancer Agents.

Zakharenko AL, Dyrkheeva NS, Luzina OA, Filimonov AS, Mozhaitsev ES, Malakhova AA, Medvedev SP, Zakian SM, Salakhutdinov NF, Lavrik OI. Zakharenko AL, et al. Genes (Basel). 2023 Oct 12;14(10):1931. doi: 10.3390/genes14101931. Genes (Basel). 2023. PMID: 37895279 Free PMC article.

10

Transcriptomic analysis of HEK293A cells with a CRISPR/Cas9-mediated TDP1 knockout.

Dyrkheeva NS, Zakharenko AL, Malakhova AA, Okorokova LS, Shtokalo DN, Medvedev SP, Tupikin AA, Kabilov MR, Lavrik OI. Dyrkheeva NS, et al. Among authors: zakharenko al. Biochim Biophys Acta Gen Subj. 2024 Apr 14;1868(7):130616. doi: 10.1016/j.bbagen.2024.130616. Online ahead of print. Biochim Biophys Acta Gen Subj. 2024. PMID: 38621596

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