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2020 4
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GAT107-mediated α7 nicotinic acetylcholine receptor signaling attenuates inflammatory lung injury and mortality in a mouse model of ventilator-associated pneumonia by alleviating macrophage mitochondrial oxidative stress via reducing MnSOD-S-glutathionylation.
Gauthier AG, Lin M, Zefi S, Kulkarni A, Thakur GA, Ashby CR Jr, Mantell LL. Gauthier AG, et al. Redox Biol. 2023 Apr;60:102614. doi: 10.1016/j.redox.2023.102614. Epub 2023 Jan 20. Redox Biol. 2023. PMID: 36717349 Free PMC article.
The nitric oxide donor, (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate (DETA-NONOate/D-NO), increases survival by attenuating hyperoxia-compromised innate immunity in bacterial clearance in a mouse model of ventilator-associated pneumonia.
Gore A, Gauthier AG, Lin M, Patel V, Thomas DD, Ashby CR Jr, Mantell LL. Gore A, et al. Among authors: gauthier ag. Biochem Pharmacol. 2020 Jun;176:113817. doi: 10.1016/j.bcp.2020.113817. Epub 2020 Jan 20. Biochem Pharmacol. 2020. PMID: 31972169 Free PMC article.
The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation.
Sitapara RA, Gauthier AG, Valdés-Ferrer SI, Lin M, Patel V, Wang M, Martino AT, Perron JC, Ashby CR Jr, Tracey KJ, Pavlov VA, Mantell LL. Sitapara RA, et al. Among authors: gauthier ag. Mol Med. 2020 Jun 29;26(1):63. doi: 10.1186/s10020-020-00177-z. Mol Med. 2020. PMID: 32600307 Free PMC article.
Correction to: 2‑O, 3‑O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1‑compromised macrophage function.
Wang M, Gauthier AG, Kennedy TP, Wang H, Velagapudi UK, Talele TT, Lin M, Wu J, Daley L, Yang X, Patel V, Mun SS, Ashby CR Jr, Mantell LL. Wang M, et al. Among authors: gauthier ag. Mol Med. 2021 Sep 3;27(1):98. doi: 10.1186/s10020-021-00354-8. Mol Med. 2021. PMID: 34479472 Free PMC article. No abstract available.
11 results