Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2014 1
2016 2
2019 3
2020 1
2023 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

8 results

Results by year

Filters applied: . Clear all
Page 1
Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.
Linciano P, Sorbi C, Rossino G, Rossi D, Marsala A, Denora N, Bedeschi M, Marino N, Miserocchi G, Dondio G, Peviani M, Tesei A, Collina S, Franchini S. Linciano P, et al. Eur J Med Chem. 2023 Mar 5;249:115163. doi: 10.1016/j.ejmech.2023.115163. Epub 2023 Jan 26. Eur J Med Chem. 2023. PMID: 36716640 Free article.
Compounds 6b and 8b were tested for cytotoxicity in-vitro against three human cancer cell lines (A549, LoVo and Panc-1) and in-vivo zebrafish model, resulting in a good efficacy/safety profile, comparable or superior to the reference drug memantine. ...
Compounds 6b and 8b were tested for cytotoxicity in-vitro against three human cancer cell lines (A549, LoVo and Panc-1) and in-vivo z …
Pathophysiological roles of autophagy and aldo-keto reductases in development of doxorubicin resistance in gastrointestinal cancer cells.
Matsunaga T, Kawabata S, Yanagihara Y, Kezuka C, Kato M, Morikawa Y, Endo S, Chen H, Iguchi K, Ikari A. Matsunaga T, et al. Chem Biol Interact. 2019 Dec 1;314:108839. doi: 10.1016/j.cbi.2019.108839. Epub 2019 Sep 26. Chem Biol Interact. 2019. PMID: 31563593
Here, we show that incubation of three human gastrointestinal cancer cell lines (HCT15, LoVo and MKN45) with doxorubicin (DOX) provokes autophagy through facilitating production of reactive oxygen species (ROS). ...In the DOX-resistant cancer cells, degree of autophagy eli …
Here, we show that incubation of three human gastrointestinal cancer cell lines (HCT15, LoVo and MKN45) with doxorubicin (DOX) provok …
Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells.
Matsunaga T, Okumura N, Saito H, Morikawa Y, Suenami K, Hisamatsu A, Endo S, Ikari A. Matsunaga T, et al. Chem Biol Interact. 2020 Dec 1;332:109295. doi: 10.1016/j.cbi.2020.109295. Epub 2020 Oct 20. Chem Biol Interact. 2020. PMID: 33096057
In this study, we established CPT11-resistant variants of three human colon cancer (DLD1, RKO and LoVo) cell lines, and found that gain of the resistance elicited an up-regulation of aldo-keto reductase (AKR) 1C3 in the cells. ...
In this study, we established CPT11-resistant variants of three human colon cancer (DLD1, RKO and LoVo) cell lines, and found that ga …
Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-gamma-dependent mechanism.
Matsunaga T, Suzuki A, Kezuka C, Okumura N, Iguchi K, Inoue I, Soda M, Endo S, El-Kabbani O, Hara A, Ikari A. Matsunaga T, et al. Chem Biol Interact. 2016 Aug 25;256:142-53. doi: 10.1016/j.cbi.2016.07.008. Epub 2016 Jul 11. Chem Biol Interact. 2016. PMID: 27417252
In this study, we investigated alterations in antioxidant molecules and functions using a newly established CDDP-resistant variant of gastric cancer MKN45 cells, and found that aldo-keto reductase 1B10 (AKR1B10) is significantly up-regulated with acquisition of the CDDP re …
In this study, we investigated alterations in antioxidant molecules and functions using a newly established CDDP-resistant variant of gastri …
Coexisting Molecular Determinants of Acquired Oxaliplatin Resistance in Human Colorectal and Ovarian Cancer Cell Lines.
Noordhuis P, Laan AC, van de Born K, Honeywell RJ, Peters GJ. Noordhuis P, et al. Int J Mol Sci. 2019 Jul 24;20(15):3619. doi: 10.3390/ijms20153619. Int J Mol Sci. 2019. PMID: 31344863 Free PMC article.
Oxaliplatin (OHP) treatment of colorectal cancer (CRC) frequently leads to resistance. OHP resistance was induced in CRC cell lines LoVo-92 and LoVo-Li and a platinum-sensitive ovarian cancer cell line, A2780, and related to cellular platinum accumulation, platinum- …
Oxaliplatin (OHP) treatment of colorectal cancer (CRC) frequently leads to resistance. OHP resistance was induced in CRC cell lines LoVo …
Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome.
Matsunaga T, Yamaji Y, Tomokuni T, Morita H, Morikawa Y, Suzuki A, Yonezawa A, Endo S, Ikari A, Iguchi K, El-Kabbani O, Tajima K, Hara A. Matsunaga T, et al. Free Radic Res. 2014 Nov;48(11):1371-85. doi: 10.3109/10715762.2014.957694. Epub 2014 Sep 23. Free Radic Res. 2014. PMID: 25156503
The incubation of the cells with a NO donor, diethylenetriamine NONOate, not only reduced the CDDP-induced cell death and apoptotic alterations (induction of CCAAT-enhancer-binding protein homologous protein and caspase-3 activation), but also elevated proteolytic activity of 26S …
The incubation of the cells with a NO donor, diethylenetriamine NONOate, not only reduced the CDDP-induced cell death and apoptotic alterati …
A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring.
Papadia P, Gandin V, Barbanente A, Ruello AG, Marzano C, Micoli K, Hoeschele JD, Natile G, Margiotta N. Papadia P, et al. RSC Adv. 2019 Oct 11;9(56):32448-32452. doi: 10.1039/c9ra07760j. eCollection 2019 Oct 10. RSC Adv. 2019. PMID: 35529760 Free PMC article.
Testing against a panel of human tumour cell lines including cervical (A431), ovarian (2008), and colon carcinomas (HCT-15 and LoVo), and two oxaliplatin-resistant clones (LoVo OXP and LoVo MDR) has shown that the new compounds have, in general, equal if not …
Testing against a panel of human tumour cell lines including cervical (A431), ovarian (2008), and colon carcinomas (HCT-15 and LoVo), …
Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position.
Savino S, Denora N, Iacobazzi RM, Porcelli L, Azzariti A, Natile G, Margiotta N. Savino S, et al. Int J Mol Sci. 2016 Jun 25;17(7):1010. doi: 10.3390/ijms17071010. Int J Mol Sci. 2016. PMID: 27347942 Free PMC article.
The novel Pt(IV) complex, cis,trans,cis-[Pt(ethanedioato)Cl{2-(2-(4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl)phenoxy)acetate)-ethanolato}(1R,2R-DACH)] (DACH = diaminocyclohexane), has been fully characterized by spectroscopic and spectrometric tech …
The novel Pt(IV) complex, cis,trans,cis-[Pt(ethanedioato)Cl{2-(2-(4-(6,8-dichloro-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-2-yl …