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Page 1
Showing results for amide
Search for Akide instead (1 results)
Applications of amide isosteres in medicinal chemistry.
Sun S, Jia Q, Zhang Z. Sun S, et al. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2535-2550. doi: 10.1016/j.bmcl.2019.07.033. Epub 2019 Jul 22. Bioorg Med Chem Lett. 2019. PMID: 31377035 Review.
Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest highlights the applications of most commonly employed amide isosteres in drug design aiming at improving potency and selectivity, optimizing physicochemical and pharmacok …
Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest highlights the applications of most c …
Amide Skeletal Elongation via Amino Acid Insertion.
Liu Z, Zhou L, Liu WH. Liu Z, et al. Chemistry. 2023 Aug 15;29(46):e202301729. doi: 10.1002/chem.202301729. Epub 2023 Jul 17. Chemistry. 2023. PMID: 37259820
Amide derivatization is useful to access valuable organic compounds considering the ready availability of molecules containing amide functionality. ...Incorporating both parts of the initial amide into the new derivatives is rare. Herein, we describe a simple …
Amide derivatization is useful to access valuable organic compounds considering the ready availability of molecules containing ami …
Transition-Metal-Free Activation of Amide Bond by Arynes.
Miyabe H. Miyabe H. Molecules. 2018 Aug 27;23(9):2145. doi: 10.3390/molecules23092145. Molecules. 2018. PMID: 30150534 Free PMC article. Review.
Highly reactive arynes activate the N-C and C=O bonds of amide groups under transition metal-free conditions. This review highlights the insertion of arynes into the N-C and C=O bonds of the amide group. ...As relative functional groups are activated, the reactions …
Highly reactive arynes activate the N-C and C=O bonds of amide groups under transition metal-free conditions. This review highlights …
Fatty acid amide signaling molecules.
Ezzili C, Otrubova K, Boger DL. Ezzili C, et al. Bioorg Med Chem Lett. 2010 Oct 15;20(20):5959-68. doi: 10.1016/j.bmcl.2010.08.048. Epub 2010 Aug 13. Bioorg Med Chem Lett. 2010. PMID: 20817522 Free PMC article. Review.
Key studies leading to the discovery and definition of the role of endogenous fatty acid amide signaling molecules are summarized....
Key studies leading to the discovery and definition of the role of endogenous fatty acid amide signaling molecules are summarized....
Heteroatom Substitution at Amide Nitrogen-Resonance Reduction and HERON Reactions of Anomeric Amides.
Glover SA, Rosser AA. Glover SA, et al. Molecules. 2018 Oct 31;23(11):2834. doi: 10.3390/molecules23112834. Molecules. 2018. PMID: 30384496 Free PMC article. Review.
This review describes how resonance in amides is greatly affected upon substitution at nitrogen by two electronegative atoms. ...In other cases the anomeric effect facilitates S(N)1 and S(N)2 reactivity at the amide nitrogen....
This review describes how resonance in amides is greatly affected upon substitution at nitrogen by two electronegative atoms. ...In o …
Amide Activation in Ground and Excited States.
Kovács E, Rózsa B, Csomos A, Csizmadia IG, Mucsi Z. Kovács E, et al. Molecules. 2018 Nov 2;23(11):2859. doi: 10.3390/molecules23112859. Molecules. 2018. PMID: 30400217 Free PMC article.
Not all amide bonds are created equally. The purpose of the present paper is the reinterpretation of the amide group by means of two concepts: amidicity and carbonylicity. ...In the current paper we demonstrate the performance of our methods to describe the chemical …
Not all amide bonds are created equally. The purpose of the present paper is the reinterpretation of the amide group by means …
Weinreb Amide Approach to the Practical Synthesis of a Key Remdesivir Intermediate.
Xie Y, Hu T, Zhang Y, Wei D, Zheng W, Zhu F, Tian G, Aisa HA, Shen J. Xie Y, et al. J Org Chem. 2021 Apr 2;86(7):5065-5072. doi: 10.1021/acs.joc.0c02986. Epub 2021 Mar 18. J Org Chem. 2021. PMID: 33733767
Adequate supplies of remdesivir are highly warranted to cope with this global public health crisis. Herein, we report a Weinreb amide approach for preparing the key intermediate of remdesivir in the glycosylation step where overaddition side reactions are eliminated. Start …
Adequate supplies of remdesivir are highly warranted to cope with this global public health crisis. Herein, we report a Weinreb amide …
An active amide group in the molecule of drugs that induce pemphigus: a casual or causal relationship?
Wolf R, Brenner S. Wolf R, et al. Dermatology. 1994;189(1):1-4. doi: 10.1159/000246749. Dermatology. 1994. PMID: 8003774 Review.
Careful analysis of the chemical structure of nonthiol drugs known to induce pemphigus revealed that several of them share an active amide group in their molecule. We believe that this group might be responsible for the induction of the disease; thus, a third group of drug …
Careful analysis of the chemical structure of nonthiol drugs known to induce pemphigus revealed that several of them share an active amid …
One-Step Biocatalytic Synthesis of Sustainable Surfactants by Selective Amide Bond Formation.
Lubberink M, Finnigan W, Schnepel C, Baldwin CR, Turner NJ, Flitsch SL. Lubberink M, et al. Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202205054. doi: 10.1002/anie.202205054. Epub 2022 Jun 8. Angew Chem Int Ed Engl. 2022. PMID: 35595679 Free PMC article.
Here, we present a biocatalytic route towards MEGAs and analogues using a truncated carboxylic acid reductase construct tailored for amide bond formation (CARmm-A). CARmm-A is capable of selective amide bond formation without the competing esterification reaction ob …
Here, we present a biocatalytic route towards MEGAs and analogues using a truncated carboxylic acid reductase construct tailored for amid …
Imidazolone as an Amide Bioisostere in the Development of beta-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors.
Jackson JJ, Siegmund AC, Bai WJ, Reed AB, Birkholz AB, Campuzano IDG, Créquer-Grandhomme A, Hu R, Modak RV, Sudom A, Javier N, Sanders C, Lo MC, Xie F, Cee VJ, Manzanillo P, Allen JG. Jackson JJ, et al. J Med Chem. 2023 Dec 14;66(23):16120-16140. doi: 10.1021/acs.jmedchem.3c01517. Epub 2023 Nov 21. J Med Chem. 2023. PMID: 37988652
B3GNT2 is responsible for elongation of cell surface long-chain polylactosamine, which influences the regulation of the immune response, making it an attractive target for immunomodulation. In the development of amide containing B3GNT2 inhibitors guided by structure-based …
B3GNT2 is responsible for elongation of cell surface long-chain polylactosamine, which influences the regulation of the immune response, mak …
672,908 results
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