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In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways.
Karasawa Y, Miyano K, Fujii H, Mizuguchi T, Kuroda Y, Nonaka M, Komatsu A, Ohshima K, Yamaguchi M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M. Karasawa Y, et al. Among authors: komatsu a. Molecules. 2021 Oct 8;26(19):6079. doi: 10.3390/molecules26196079. Molecules. 2021. PMID: 34641621 Free PMC article.
Novel Opioid Analgesics for the Development of Transdermal Opioid Patches That Possess Morphine-Like Pharmacological Profiles Rather Than Fentanyl: Possible Opioid Switching Alternatives Among Patch Formula.
Komatsu A, Miyano K, Nakayama D, Mizobuchi Y, Uezono E, Ohshima K, Karasawa Y, Kuroda Y, Nonaka M, Yamaguchi K, Iseki M, Uezono Y, Hayashida M. Komatsu A, et al. Anesth Analg. 2022 May 1;134(5):1082-1093. doi: 10.1213/ANE.0000000000005954. Anesth Analg. 2022. PMID: 35427270 Free PMC article.
Evaluation of the Intracellular Signaling Activities of κ-Opioid Receptor Agonists, Nalfurafine Analogs; Focusing on the Selectivity of G-Protein- and β-Arrestin-Mediated Pathways.
Yamaguchi M, Miyano K, Hirayama S, Karasawa Y, Ohshima K, Uezono E, Komatsu A, Nonaka M, Fujii H, Yamaguchi K, Iseki M, Hayashida M, Uezono Y. Yamaguchi M, et al. Among authors: komatsu a. Molecules. 2022 Oct 19;27(20):7065. doi: 10.3390/molecules27207065. Molecules. 2022. PMID: 36296658 Free PMC article.
Distinct Profiles of Desensitization of µ-Opioid Receptors Caused by Remifentanil or Fentanyl: In Vitro Assay with Cells and Three-Dimensional Structural Analyses.
Uezono E, Mizobuchi Y, Miyano K, Ohbuchi K, Murata H, Komatsu A, Manabe S, Nonaka M, Hirokawa T, Yamaguchi K, Iseki M, Uezono Y, Hayashida M, Kawagoe I. Uezono E, et al. Among authors: komatsu a. Int J Mol Sci. 2023 May 6;24(9):8369. doi: 10.3390/ijms24098369. Int J Mol Sci. 2023. PMID: 37176075 Free PMC article.
Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors.
Kuroda Y, Nonaka M, Kamikubo Y, Ogawa H, Murayama T, Kurebayashi N, Sakairi H, Miyano K, Komatsu A, Dodo T, Nakano-Ito K, Yamaguchi K, Sakurai T, Iseki M, Hayashida M, Uezono Y. Kuroda Y, et al. Among authors: komatsu a. Biomed Pharmacother. 2021 Sep;141:111800. doi: 10.1016/j.biopha.2021.111800. Epub 2021 Jun 24. Biomed Pharmacother. 2021. PMID: 34175819 Free article.