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3',4'-Bis(4-chlorophenyl)spiro[chroman-3,5'(4'H)-isoxazol]-4-one.
Ajees AA, Parthasarathy S, Manikandan S, Raghunathan R. Ajees AA, et al. Acta Crystallogr C. 2001 Apr;57(Pt 4):473-5. doi: 10.1107/s0108270101000920. Acta Crystallogr C. 2001. PMID: 11313598
The five-membered spiroisoxazoline ring is in an envelope conformation. The p-chlorophenyl rings bridged by the five-membered ring are nearly perpendicular to each other. The chromanone moiety of one molecule packs into the cavity formed by the p-chlorophenyl rings …
The five-membered spiroisoxazoline ring is in an envelope conformation. The p-chlorophenyl rings bridged by the five-membered ring ar …
Role of signature lysines in the deviant walker a motifs of the ArsA ATPase.
Fu HL, Ajees AA, Rosen BP, Bhattacharjee H. Fu HL, et al. Among authors: ajees aa. Biochemistry. 2010 Jan 19;49(2):356-64. doi: 10.1021/bi901681v. Biochemistry. 2010. PMID: 20000479 Free PMC article.
The ArsA ATPase belongs to the P-loop GTPase subgroup within the GTPase superfamily of proteins. ...
The ArsA ATPase belongs to the P-loop GTPase subgroup within the GTPase superfamily of proteins. ...
Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1.
Jiang X, McDermott JR, Ajees AA, Rosen BP, Liu Z. Jiang X, et al. Among authors: ajees aa. Metallomics. 2010 Mar;2(3):211-9. doi: 10.1039/b920471g. Epub 2009 Dec 8. Metallomics. 2010. PMID: 21069159 Free PMC article.
The K(m) for uptake of CH3As(OH)2 of three identified mutants, S66F, R126K and T310I, were decreased 4-10 fold compared to native GLUT1. The osmotic water permeability coefficient (P(f)) of GLUT1 and the three clinical isolates increased in parallel with the rate of CH3As( …
The K(m) for uptake of CH3As(OH)2 of three identified mutants, S66F, R126K and T310I, were decreased 4-10 fold compared to native GLUT1. The …