Cytokine gene polymorphisms in Iraqi Arabs

Ali H Ad'hiah; Zahra'a A Ahmed; Milad A Al-Naseri; Ehab D Salman; Osama B Al-Saffar; Hiba S Ahmed; Talib A Hussain; Ekhlass M Idan; Ibtesam B Hassan; Batool A Shihab; Lateef O Mohammed; Fatima S Al-Nasiri

doi:10.1016/j.humimm.2017.12.009

Cytokine gene polymorphisms in Iraqi Arabs

Hum Immunol. 2018 Feb;79(2):91-92. doi: 10.1016/j.humimm.2017.12.009. Epub 2017 Dec 27.

Authors

Affiliations

¹ Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq. Electronic address: dr.a.h.adhiah@gmail.com.
² Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq.
³ Sera and Vaccine Institute, Ministry of Health, Baghdad, Iraq.
⁴ Department of Biotechnology, College of Science, University of Baghdad, Baghdad, Iraq.
⁵ Department of Biology, Madenat Alelem University College, Baghdad, Iraq.
⁶ Department of Microbiology, College of Science, Al-karkh University of Science, Baghdad, Iraq.
⁷ Department of Life Sciences, College of Education for Pure Sciences, University of Diyala, Diyala, Iraq.
⁸ Department of Medical Microbiology, College of Medicine, University of Sulaimania, Sulaimania, Iraq.
⁹ Department of Biology, College of Science, University of Tikrit, Tikrit, Iraq.

PMID: 29288696
DOI: 10.1016/j.humimm.2017.12.009

Abstract

In this report, 224 unrelated healthy Iraqi Arabs (102 males and 122 females) were genotyped for 22 SNPs (single nucleotide polymorphisms) belong to 13 cytokine genes (IL1A, IL1B, IL1RA, IL1R, IL2, IL4, IL4R, IL6, IL10, IL12, IFNG, TNFA and TGFB1). The method of detection was PCR-SSP (polymerase chain reaction-sequence specific primer). The data were presented in terms of allele and genotype frequencies. Two-locus haplotype frequencies were also estimated for some SNPs. Genotype frequencies of detected cytokine gene polymorphisms are available in the Database of Allele Frequencies Net under the AFND number 3422 and the population name "Iraq Arab Cytokine".

Keywords: Cytokine; Haplotype; Iraqi Arabs; SNPs.

MeSH terms

Adolescent
Adult
Aged
Arabs*
Child
Child, Preschool
Cytokines / genetics*
Female
Gene Frequency
Genotype*
Haplotypes
Humans
Infant
Iraq
Male
Middle Aged
Polymorphism, Single Nucleotide
Young Adult

Substances

Cytokines