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1880 3
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1887 2
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1896 2
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1920 1
1921 2
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1935 3
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1984 134
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1986 135
1987 133
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1989 178
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1992 181
1993 1067
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1995 239
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1998 321
1999 380
2000 464
2001 566
2002 686
2003 692
2004 773
2005 932
2006 1030
2007 1111
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2010 1420
2011 1512
2012 1600
2013 1832
2014 2109
2015 2301
2016 2041
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2018 2206
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2020 2781
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The following term was not found in PubMed: Ogilvie-Smith
Page 1
The ADAM metalloproteinases.
Edwards DR, Handsley MM, Pennington CJ. Edwards DR, et al. Mol Aspects Med. 2008 Oct;29(5):258-89. doi: 10.1016/j.mam.2008.08.001. Epub 2008 Aug 15. Mol Aspects Med. 2008. PMID: 18762209 Free PMC article. Review.
In particular, ADAM-17 is required for generation of the active forms of Epidermal Growth Factor Receptor (EGFR) ligands, and its function is essential for the development of epithelial tissues. Several other ADAMs have important sheddase functions in particular tissue con …
In particular, ADAM-17 is required for generation of the active forms of Epidermal Growth Factor Receptor (EGFR) ligands, and its fun …
Necroptosis, ADAM proteases and intestinal (dys)function.
Heib M, Rose-John S, Adam D. Heib M, et al. Int Rev Cell Mol Biol. 2020;353:83-152. doi: 10.1016/bs.ircmb.2020.02.001. Epub 2020 Mar 5. Int Rev Cell Mol Biol. 2020. PMID: 32381179 Review.
Equally important for organismal homeostasis, ADAM proteases control cellular processes such as development and differentiation, immune responses or tissue regeneration. Notably, necroptosis as well as ADAM proteases have been implicated in the control of inflammato …
Equally important for organismal homeostasis, ADAM proteases control cellular processes such as development and differentiation, immu …
Inhibition of MMPs and ADAM/ADAMTS.
Malemud CJ. Malemud CJ. Biochem Pharmacol. 2019 Jul;165:33-40. doi: 10.1016/j.bcp.2019.02.033. Epub 2019 Feb 28. Biochem Pharmacol. 2019. PMID: 30826330 Free PMC article. Review.
Under normal conditions, MMP, ADAM and ADAMTS gene expression aids in the maintenance of homeostasis. However, in inflamed synovial joints characteristic of rheumatoid arthritis and osteoarthritis. MMP, ADAM and ADAMTS production is greatly increased under the influ …
Under normal conditions, MMP, ADAM and ADAMTS gene expression aids in the maintenance of homeostasis. However, in inflamed synovial j …
ADAM-17: the enzyme that does it all.
Gooz M. Gooz M. Crit Rev Biochem Mol Biol. 2010 Apr;45(2):146-69. doi: 10.3109/10409231003628015. Crit Rev Biochem Mol Biol. 2010. PMID: 20184396 Free PMC article. Review.
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme (TACE), ADAM-17 has been reported to be an indispensible regulator of almost every cellular event from proliferation to migration. The central role …
This review focuses on the role of ADAM-17 in disease. Since its debut as the tumor necrosis factor converting enzyme (TACE), ADAM …
SNPs in ADAMTS13.
Tseng SC, Kimchi-Sarfaty C. Tseng SC, et al. Pharmacogenomics. 2011 Aug;12(8):1147-60. doi: 10.2217/pgs.11.66. Pharmacogenomics. 2011. PMID: 21843064 Review.
ADAM Metalloproteinases as Potential Drug Targets.
Camodeca C, Cuffaro D, Nuti E, Rossello A. Camodeca C, et al. Curr Med Chem. 2019;26(15):2661-2689. doi: 10.2174/0929867325666180326164104. Curr Med Chem. 2019. PMID: 29589526 Review.
Thrombotic microangiopathy syndromes.
Zakarija A. Zakarija A. Cancer Treat Res. 2009;148:115-36. doi: 10.1007/978-0-387-79962-9_8. Cancer Treat Res. 2009. PMID: 19377922 Review. No abstract available.
ADAM-Mediated Signalling Pathways in Gastrointestinal Cancer Formation.
Schumacher N, Rose-John S, Schmidt-Arras D. Schumacher N, et al. Int J Mol Sci. 2020 Jul 20;21(14):5133. doi: 10.3390/ijms21145133. Int J Mol Sci. 2020. PMID: 32698506 Free PMC article. Review.
Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiators of paracrine signal transduction. In this review, we summarize the current knowledge on how ADAM proteases on tumour cells but also …
Members of the family of A disintegrin and metalloproteases (ADAM) are major mediators of ectodomain shedding and therefore initiator …
The role of A Disintegrin and Metalloproteinase (ADAM)-10 in T helper cell biology.
Sezin T, Selvakumar B, Scheffold A. Sezin T, et al. Biochim Biophys Acta Mol Cell Res. 2022 Apr;1869(4):119192. doi: 10.1016/j.bbamcr.2021.119192. Epub 2022 Jan 1. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 34982961 Free article. Review.
The complexity of both, the ADAM substrate expression as well as the functional consequences of ADAM-mediated cleavage of the various substrates complicates the analysis of cell type specific effects. Here we provide an overview on the major ADAM-10 substrate …
The complexity of both, the ADAM substrate expression as well as the functional consequences of ADAM-mediated cleavage of the …
ADAM8 in allergy.
Matsuno O, Kumamoto T, Higuchi Y. Matsuno O, et al. Inflamm Allergy Drug Targets. 2008 Jun;7(2):108-12. doi: 10.2174/187152808785107598. Inflamm Allergy Drug Targets. 2008. PMID: 18691140 Review.
ADAM (a disintegrin and metalloprotease) family members are membrane-anchored proteins with wide ranging functions, including proteolytic cleavage of cell surface molecules, cell fusion, cell adhesion and intracellular signaling. ...
ADAM (a disintegrin and metalloprotease) family members are membrane-anchored proteins with wide ranging functions, including proteol …
41,412 results
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