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NPP-669, a Novel Broad-Spectrum Antiviral Therapeutic with Excellent Cellular Uptake, Antiviral Potency, Oral Bioavailability, Preclinical Efficacy, and a Promising Safety Margin.
Lipka E, Chadderdon AM, Harteg CC, Doherty MK, Simon ES, Domagala JM, Reyna DM, Hutchings KM, Gan X, White AD, Hartline CB, Harden EA, Keith KA, Prichard MN, James SH, Cardin RD, Bernstein DI, Spencer JF, Tollefson AE, Wold WSM, Toth K. Lipka E, et al. Among authors: chadderdon am. Mol Pharm. 2023 Jan 2;20(1):370-382. doi: 10.1021/acs.molpharmaceut.2c00668. Epub 2022 Dec 9. Mol Pharm. 2023. PMID: 36484496 Free PMC article.
The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments.
Wang M, Irvin TC, Herdman CA, Hanna RD, Hassan SA, Lee YS, Kaska S, Crowley RS, Prisinzano TE, Withey SL, Paronis CA, Bergman J, Inan S, Geller EB, Adler MW, Kopajtic TA, Katz JL, Chadderdon AM, Traynor JR, Jacobson AE, Rice KC. Wang M, et al. Among authors: chadderdon am. Molecules. 2020 Jun 6;25(11):2640. doi: 10.3390/molecules25112640. Molecules. 2020. PMID: 32517185 Free PMC article.
Modulation of opioid receptor affinity and efficacy via N-substitution of 9β-hydroxy-5-(3-hydroxyphenyl)morphan: Synthesis and computer simulation study.
Truong PM, Hassan SA, Lee YS, Kopajtic TA, Katz JL, Chadderdon AM, Traynor JR, Deschamps JR, Jacobson AE, Rice KC. Truong PM, et al. Among authors: chadderdon am. Bioorg Med Chem. 2017 Apr 15;25(8):2406-2422. doi: 10.1016/j.bmc.2017.02.064. Epub 2017 Mar 1. Bioorg Med Chem. 2017. PMID: 28314512 Free PMC article.