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Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.
Sörmann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel EB, Agre KE, Begtrup A, Dean J, Descartes M, Fischer J, Gardham A, Lahner C, Mark PR, Muppidi S, Pichurin PN, Porrmann J, Schallner J, Smith K, Straub V, Vasudevan P, Willaert R, Carpenter EP, Rödström KEJ, Hahn MG, Müller T, Baukrowitz T, Hurles ME, Wright CF, Tucker SJ. Sörmann J, et al. Nat Genet. 2022 Oct;54(10):1534-1543. doi: 10.1038/s41588-022-01185-x. Epub 2022 Oct 4. Nat Genet. 2022. PMID: 36195757 Free PMC article.
Sleep apnea is a common disorder that represents a global public health burden. KCNK3 encodes TASK-1, a K(+) channel implicated in the control of breathing, but its link with sleep apnea remains poorly understood. ...
Sleep apnea is a common disorder that represents a global public health burden. KCNK3 encodes TASK-1, a K(+) channel implicate …
Trans-Thoracic Extra-Pleural Percutaneous Spinal Fixation-A Technical Note.
Krishnan SS, Nigam P, Vasudevan MC. Krishnan SS, et al. Neurol India. 2022 May-Jun;70(3):1154-1158. doi: 10.4103/0028-3886.349593. Neurol India. 2022. PMID: 35864654 Free article.
Stab incision is made and screws placed percutaneously through a K-wire-defined trajectory. RESULTS: Eighteen patients underwent fixation through this technique, of which 11 were infectious, four were traumatic, and the rest were neoplastic in pathology. ...
Stab incision is made and screws placed percutaneously through a K-wire-defined trajectory. RESULTS: Eighteen patients underwe …
A model of the generation and transport of ozone in high-tension nozzle driven corona inside a novel diode.
Vijayan T, Patil JG. Vijayan T, et al. Rev Sci Instrum. 2012 Dec;83(12):123304. doi: 10.1063/1.4770130. Rev Sci Instrum. 2012. PMID: 23277979
The nozzles played the dual role of oxygen (O(2)) injection as well as creation of high electric field (E) in the A-K gap, enabled the formation of a cold corona. Electrons in the corona under the influence of E moved towards anode, collided with O(2) and created th …
The nozzles played the dual role of oxygen (O(2)) injection as well as creation of high electric field (E) in the A-K gap, ena …
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.
Yin Z, Patel SJ, Wang WL, Wang G, Chan WL, Rao KR, Alam J, Jeyaraj DA, Ngew X, Patel V, Beer D, Lim SP, Vasudevan SG, Keller TH. Yin Z, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):36-9. doi: 10.1016/j.bmcl.2005.09.062. Epub 2005 Oct 21. Bioorg Med Chem Lett. 2006. PMID: 16246553
Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic acid. A boronic acid has the highest affinity, exhibiting a K(i) of 43 nM....
Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluoromethyl ketone, and boronic ac …
Monoclonal antibodies against dengue NS2B and NS3 proteins for the study of protein interactions in the flaviviral replication complex.
Moreland NJ, Tay MY, Lim E, Rathore AP, Lim AP, Hanson BJ, Vasudevan SG. Moreland NJ, et al. J Virol Methods. 2012 Jan;179(1):97-103. doi: 10.1016/j.jviromet.2011.10.006. Epub 2011 Oct 20. J Virol Methods. 2012. PMID: 22040846
The NS3 helicase domain competes with NS3 full-length for NS5 RdRp binding, with a K(d.) of 2.5muM. Since NS3 and NS5 are required for DENV replication, this fascile assay could be used to screen for non-nucleoside, allosteric inhibitors that disrupt the interaction …
The NS3 helicase domain competes with NS3 full-length for NS5 RdRp binding, with a K(d.) of 2.5muM. Since NS3 and NS5 are requ …
Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization.
Menard MT, Farber A, Powell RJ, Rosenfield K, Conte MS, Hamza TH, Kaufman JA, Cziraky MJ, Creager MA, Dake MD, Jaff MR, Reid D, Sopko G, White CJ, Strong MB, van Over M, Chisci E, Goodney PP, Gray B, Kayssi A, Siracuse JJ, Choudhry NK; BEST-CLI Investigators. Menard MT, et al. Circulation. 2024 Apr 16;149(16):1241-1253. doi: 10.1161/CIRCULATIONAHA.123.065277. Epub 2024 Apr 10. Circulation. 2024. PMID: 38597097 Free article. Clinical Trial.