Characterization of the invitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line.
Nunes HL, Tuttis K, Serpeloni JM, Nascimento JRD, da Rocha CQ, Silva VAO, Lengert AVH, Reis RM, de Syllos Cólus IM.
Nunes HL, et al.
J Toxicol Environ Health A. 2020 Aug 17;83(15-16):547-558. doi: 10.1080/15287394.2020.1784339. Epub 2020 Jun 26.
J Toxicol Environ Health A. 2020.
PMID: 32590922
The IC(50) values for brachydins BrA, BrB, and BrC were 23.41, 4.28, and 4.44 M, respectively, and all compounds induced apoptosis and necrosis. BrB and BrC increased p21 levels indicating a possible G1 cell cycle arrest. BrA (6 M) and BrB (3.84 M) decreased …
The IC(50) values for brachydins BrA, BrB, and BrC were 23.41, 4.28, and 4.44 M, respectively, and all compounds induced apoptosis an …