Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin.
Clay ME, Hammond JH, Zhong F, Chen X, Kowalski CH, Lee AJ, Porter MS, Hampton TH, Greene CS, Pletneva EV, Hogan DA.
Clay ME, et al.
Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):3167-3173. doi: 10.1073/pnas.1917576117. Epub 2020 Jan 24.
Proc Natl Acad Sci U S A. 2020.
PMID: 31980538
Free PMC article.
Purified P. aeruginosa Mhr protein contained the predicted di-iron center and bound molecular oxygen with an apparent K(d) of 1 M. Both Anr and Mhr were necessary for fitness in lasR+ and lasR mutant strains in colony biofilms grown in microoxic conditions, and the effects …
Purified P. aeruginosa Mhr protein contained the predicted di-iron center and bound molecular oxygen with an apparent K(d) of 1 M. Bo …