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1959 3
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1962 1
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1970 2
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1973 1
1974 5
1975 1
1976 3
1977 2
1978 1
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1980 5
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1984 9
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1987 3
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1990 17
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1994 6
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1996 8
1997 3
1998 3
1999 6
2000 6
2001 11
2002 9
2003 5
2004 14
2005 16
2006 16
2007 24
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1,396 results

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LecA (PA-IL): A Galactose-Binding Lectin from Pseudomonas aeruginosa.
Kuhaudomlarp S, Gillon E, Varrot A, Imberty A. Kuhaudomlarp S, et al. Methods Mol Biol. 2020;2132:257-266. doi: 10.1007/978-1-0716-0430-4_25. Methods Mol Biol. 2020. PMID: 32306333
LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. ...
LecA/PA-IL (Pfam PF07828) is a soluble galactose-binding lectin from bacterium Pseudomonas aeruginosa. ...
Targeting Bacterial Biofilm: A New LecA Multivalent Ligand with Inhibitory Activity.
Palmioli A, Sperandeo P, Polissi A, Airoldi C. Palmioli A, et al. Chembiochem. 2019 Dec 2;20(23):2911-2915. doi: 10.1002/cbic.201900383. Epub 2019 Sep 24. Chembiochem. 2019. PMID: 31216375 Free article.
Infections caused by Pseudomonas aeruginosa are of great concern, especially for immunocompromised and cystic fibrosis patients. P. aeruginosa lectins LecA and LecB are virulence factors and play a key role in establishing biofilm; therefore, inhibition of the function of …
Infections caused by Pseudomonas aeruginosa are of great concern, especially for immunocompromised and cystic fibrosis patients. P. aerugino …
LUCA to LECA, the Lucacene: A model for the gigayear delay from the first prokaryote to eukaryogenesis.
Mikhailovsky GE, Gordon R. Mikhailovsky GE, et al. Biosystems. 2021 Jul;205:104415. doi: 10.1016/j.biosystems.2021.104415. Epub 2021 Apr 1. Biosystems. 2021. PMID: 33812918
It is puzzling why life on Earth consisted of prokaryotes for up to 2.5 0.5 billion years (Gy) before the appearance of the first eukaryotes. This period, from LUCA (Last Universal Common Ancestor) to LECA (Last Eucaryotic Common Ancestor), we have named the Lucacene, to s …
It is puzzling why life on Earth consisted of prokaryotes for up to 2.5 0.5 billion years (Gy) before the appearance of the first eukaryotes …
Functionalization of a Rigid Divalent Ligand for LecA, a Bacterial Adhesion Lectin.
Fu O, Pukin AV, Quarles van Ufford HC, Kemmink J, de Mol NJ, Pieters RJ. Fu O, et al. ChemistryOpen. 2015 Aug;4(4):463-70. doi: 10.1002/open.201402171. Epub 2015 Mar 9. ChemistryOpen. 2015. PMID: 26478841 Free PMC article.
The bacterial adhesion lectin LecA is an attractive target for interference with the infectivity of its producer P. aeruginosa. ...The introduction of positively charged, negatively charged, and also lipophilic functional groups was successful. The compounds were good L …
The bacterial adhesion lectin LecA is an attractive target for interference with the infectivity of its producer P. aeruginosa. ...Th …
The virome of the last eukaryotic common ancestor and eukaryogenesis.
Krupovic M, Dolja VV, Koonin EV. Krupovic M, et al. Nat Microbiol. 2023 Jun;8(6):1008-1017. doi: 10.1038/s41564-023-01378-y. Epub 2023 May 1. Nat Microbiol. 2023. PMID: 37127702 Review.
To gain insight into LECA biology and eukaryogenesis-the origin of the eukaryotic cell, which remains poorly understood-we reconstructed the LECA virus repertoire. ...The origin of the LECA virome can be traced back to a small set of bacterial-not archaeal-vi …
To gain insight into LECA biology and eukaryogenesis-the origin of the eukaryotic cell, which remains poorly understood-we reconstruc …
A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate.
Zahorska E, Kuhaudomlarp S, Minervini S, Yousaf S, Lepsik M, Kinsinger T, Hirsch AKH, Imberty A, Titz A. Zahorska E, et al. Chem Commun (Camb). 2020 Aug 4;56(62):8822-8825. doi: 10.1039/d0cc03490h. Chem Commun (Camb). 2020. PMID: 32628229
Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin LecA is a virulence factor and an anti-biofilm drug target. Increasing the overall binding affinity by multivalent presentation of bi …
Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin …
Expression, purification, and evaluation of recombinant LecA as a candidate for an amebic colitis vaccine.
Barroso L, Abhyankar M, Noor Z, Read K, Pedersen K, White R, Fox C, Petri WA Jr, Lyerly D. Barroso L, et al. Vaccine. 2014 Feb 26;32(10):1218-24. doi: 10.1016/j.vaccine.2013.06.056. Epub 2013 Jul 1. Vaccine. 2014. PMID: 23827311 Free PMC article.
We developed a purification process for preparing highly purified non-tagged LecA using a codon-optimized gene expressed in Escherichia coli. ...Immunization of CBA mice with LecA resulted in significant protection against cecal colitis. Our procedure yields suffici …
We developed a purification process for preparing highly purified non-tagged LecA using a codon-optimized gene expressed in Escherich …
A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa.
Novoa A, Eierhoff T, Topin J, Varrot A, Barluenga S, Imberty A, Römer W, Winssinger N. Novoa A, et al. Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8885-9. doi: 10.1002/anie.201402831. Epub 2014 Jul 7. Angew Chem Int Ed Engl. 2014. PMID: 25044671
Lectin LecA is a virulence factor of Pseudomonas aeruginosa involved in lung injury, mortality, and cellular invasion. ...We have identified a novel divalent ligand from a focused galactoside(Gal)-conjugate array which binds to LecA with very high affinity (Kd = 82 …
Lectin LecA is a virulence factor of Pseudomonas aeruginosa involved in lung injury, mortality, and cellular invasion. ...We have ide …
Concepts of the last eukaryotic common ancestor.
O'Malley MA, Leger MM, Wideman JG, Ruiz-Trillo I. O'Malley MA, et al. Nat Ecol Evol. 2019 Mar;3(3):338-344. doi: 10.1038/s41559-019-0796-3. Epub 2019 Feb 18. Nat Ecol Evol. 2019. PMID: 30778187 Review.
For instance, how does this concept affect standard expectations about the ecology, geography, fitness, and diversification of LECA? Does it affect evolutionary interpretations of LECA's cellular functions? ...Our aim is to add to the conceptual toolkit for developi …
For instance, how does this concept affect standard expectations about the ecology, geography, fitness, and diversification of LECA? …
1,396 results