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68 results

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ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway in breast cancer.
Wang S, Böhnert V, Joseph AJ, Sudaryo V, Skariah G, Swinderman JT, Yu FB, Subramanyam V, Wolf DM, Lyu X, Gilbert LA, Van't Veer LJ, Goodarzi H, Li L. Wang S, et al. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2313693120. doi: 10.1073/pnas.2313693120. Epub 2023 Dec 20. Proc Natl Acad Sci U S A. 2023. PMID: 38117852 Free PMC article.
Human-like scene interpretation by a guided counterstream processing.
Ullman S, Assif L, Strugatski A, Vatashsky BZ, Levi H, Netanyahu A, Yaari A. Ullman S, et al. Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2211179120. doi: 10.1073/pnas.2211179120. Epub 2023 Sep 28. Proc Natl Acad Sci U S A. 2023. PMID: 37769256 Free PMC article.
In contrast with scene graphs, humans' scene perception focuses on selected structures in the scene, starting with a limited interpretation and evolving sequentially in a goal-directed manner [G. L. Malcolm, I. I. A. Groen, C. I. Baker, Trends. Cogn. Sci. 20, 843-85 …
In contrast with scene graphs, humans' scene perception focuses on selected structures in the scene, starting with a limited interpretation …
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
Ridker PM, Revkin J, Amarenco P, Brunell R, Curto M, Civeira F, Flather M, Glynn RJ, Gregoire J, Jukema JW, Karpov Y, Kastelein JJP, Koenig W, Lorenzatti A, Manga P, Masiukiewicz U, Miller M, Mosterd A, Murin J, Nicolau JC, Nissen S, Ponikowski P, Santos RD, Schwartz PF, Soran H, White H, Wright RS, Vrablik M, Yunis C, Shear CL, Tardif JC; SPIRE Cardiovascular Outcome Investigators. Ridker PM, et al. N Engl J Med. 2017 Apr 20;376(16):1527-1539. doi: 10.1056/NEJMoa1701488. Epub 2017 Mar 17. N Engl J Med. 2017. PMID: 28304242 Free article. Clinical Trial.
Characterization of a new SARS-CoV-2 variant that emerged in Brazil.
Imai M, Halfmann PJ, Yamayoshi S, Iwatsuki-Horimoto K, Chiba S, Watanabe T, Nakajima N, Ito M, Kuroda M, Kiso M, Maemura T, Takahashi K, Loeber S, Hatta M, Koga M, Nagai H, Yamamoto S, Saito M, Adachi E, Akasaka O, Nakamura M, Nakachi I, Ogura T, Baba R, Fujita K, Ochi J, Mitamura K, Kato H, Nakajima H, Yagi K, Hattori SI, Maeda K, Suzuki T, Miyazato Y, Valdez R, Gherasim C, Furusawa Y, Okuda M, Ujie M, Lopes TJS, Yasuhara A, Ueki H, Sakai-Tagawa Y, Eisfeld AJ, Baczenas JJ, Baker DA, O'Connor SL, O'Connor DH, Fukushi S, Fujimoto T, Kuroda Y, Gordon A, Maeda K, Ohmagari N, Sugaya N, Yotsuyanagi H, Mitsuya H, Suzuki T, Kawaoka Y. Imai M, et al. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106535118. doi: 10.1073/pnas.2106535118. Proc Natl Acad Sci U S A. 2021. PMID: 34140350 Free PMC article.
In hamsters, the variant showed replicative abilities and pathogenicity similar to those of early and contemporary strains (i.e., SARS-CoV-2 bearing aspartic acid [D] or glycine [G] at position 614 of the S protein). Sera and/or plasma from convalescent patients and BNT162 …
In hamsters, the variant showed replicative abilities and pathogenicity similar to those of early and contemporary strains (i.e., SARS-CoV-2 …
Eight-coordinate fluoride in a silicate double-four-ring.
Goesten MG, Hoffmann R, Bickelhaupt FM, Hensen EJ. Goesten MG, et al. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):828-833. doi: 10.1073/pnas.1615742114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096342 Free PMC article.
Sex-specific regulation of Lgr3 in Drosophila neurons.
Meissner GW, Luo SD, Dias BG, Texada MJ, Baker BS. Meissner GW, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1256-65. doi: 10.1073/pnas.1600241113. Epub 2016 Feb 16. Proc Natl Acad Sci U S A. 2016. PMID: 26884206 Free PMC article.
Several direct targets of Dsx have been identified, but direct Fru targets have not been definitively identified. We show that Drosophila leucine-rich repeat G protein-coupled receptor 3 (Lgr3) is regulated by Fru and Dsx in separate populations of neurons. ...
Several direct targets of Dsx have been identified, but direct Fru targets have not been definitively identified. We show that Drosophila le …
Computational design of a pH-sensitive IgG binding protein.
Strauch EM, Fleishman SJ, Baker D. Strauch EM, et al. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):675-80. doi: 10.1073/pnas.1313605111. Epub 2013 Dec 31. Proc Natl Acad Sci U S A. 2014. PMID: 24381156 Free PMC article.
We used de novo protein interface design to generate a pH-dependent Fc domain binding protein that buries immunoglobulin G (IgG) His-433. Using next-generation sequencing of naive and selected pools of a library of design variants, we generated a molecular footprint of the …
We used de novo protein interface design to generate a pH-dependent Fc domain binding protein that buries immunoglobulin G (IgG) His- …
Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.
Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR. Redfern CH, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4826-31. doi: 10.1073/pnas.97.9.4826. Proc Natl Acad Sci U S A. 2000. PMID: 10781088 Free PMC article.
Using the tetracycline transactivator system and a modified G(i)-coupled receptor (Ro1), we provide evidence that increased G(i) signaling in mice can result in a lethal cardiomyopathy associated with a wide QRS complex arrhythmia. ...Our system allows cardiomyopath …
Using the tetracycline transactivator system and a modified G(i)-coupled receptor (Ro1), we provide evidence that increased G( …
Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production.
Huang M, Wang G, Qin J, Petranovic D, Nielsen J. Huang M, et al. Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11025-E11032. doi: 10.1073/pnas.1809921115. Epub 2018 Nov 5. Proc Natl Acad Sci U S A. 2018. PMID: 30397111 Free PMC article.
Baker's yeast Saccharomyces cerevisiae is one of the most important and widely used cell factories for recombinant protein production. ...Through combinatorial genetic manipulations of several of the newly identified gene targets, we enhanced the protein production capacit
Baker's yeast Saccharomyces cerevisiae is one of the most important and widely used cell factories for recombinant protein production
Long-term benefits of nonpharmaceutical interventions for endemic infections are shaped by respiratory pathogen dynamics.
Baker RE, Saad-Roy CM, Park SW, Farrar J, Metcalf CJE, Grenfell BT. Baker RE, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2208895119. doi: 10.1073/pnas.2208895119. Epub 2022 Nov 29. Proc Natl Acad Sci U S A. 2022. PMID: 36445971 Free PMC article.
Our results underline that managing ongoing susceptible buildup, e.g., with vaccination, remains an important long-term goal....
Our results underline that managing ongoing susceptible buildup, e.g., with vaccination, remains an important long-term goal....
68 results