Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam.
Pemberton OA, Noor RE, Kumar M V V, Sanishvili R, Kemp MT, Kearns FL, Woodcock HL, Gelis I, Chen Y.
Pemberton OA, et al.
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5818-5825. doi: 10.1073/pnas.1922203117. Epub 2020 Mar 2.
Proc Natl Acad Sci U S A. 2020.
PMID: 32123084
Free PMC article.
To help unravel the ambiguity surrounding class A beta-lactamase catalysis, we have used ultrahigh-resolution X-ray crystallography and the recently approved beta-lactamase inhibitor avibactam to trap the acyl-enzyme complex of class A beta-lactamase CTX-M-14 at varying pH …
To help unravel the ambiguity surrounding class A beta-lactamase catalysis, we have used ultrahigh-resolution X-ray crystallography and the …