K(V)1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity.
Kuzmenkov AI, Nekrasova OV, Peigneur S, Tabakmakher VM, Gigolaev AM, Fradkov AF, Kudryashova KS, Chugunov AO, Efremov RG, Tytgat J, Feofanov AV, Vassilevski AA.
Kuzmenkov AI, et al.
Neuropharmacology. 2018 Dec;143:228-238. doi: 10.1016/j.neuropharm.2018.09.030. Epub 2018 Sep 22.
Neuropharmacology. 2018.
PMID: 30248306
MeKTx11-1 is a high-affinity blocker of K(V)1.2 (IC(50) 0.2 nM), while its activity against K(V)1.1, K(V)1.3, and K(V)1.6 is 10 000, 330 and 45 000 fold lower, respectively, as measured using the voltage-clamp technique on mammalian channels expressed …
MeKTx11-1 is a high-affinity blocker of K(V)1.2 (IC(50) 0.2 nM), while its activity against K(V)1.1, K(V)1.3, and K( …