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Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
Zhou J, Zeng Y, Cui L, Chen X, Stauffer S, Wang Z, Yu F, Lele SM, Talmon GA, Black AR, Chen Y, Dong J. Zhou J, et al. Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6760-E6769. doi: 10.1073/pnas.1800621115. Epub 2018 Jul 2. Proc Natl Acad Sci U S A. 2018. PMID: 29967145 Free PMC article.
However, little is known about the mechanisms by which Zyxin itself is regulated and how Zyxin affects Hippo-YAP activity. ...Mitotic phosphorylation is required for Zyxin activity in promoting growth. Zyxin regulates YAP activity through the colon can …
However, little is known about the mechanisms by which Zyxin itself is regulated and how Zyxin affects Hippo-YAP activity. ... …
Endothelial knockdown of the tumor suppressor, WWOX, increases inflammation in ventilator-induced lung injury.
Zeng Z, Abdelwahid E, Chen W, Ascoli C, Pham T, Jacobson JR, Dudek SM, Natarajan V, Aldaz CM, Machado RF, Singla S. Zeng Z, et al. Am J Physiol Lung Cell Mol Physiol. 2024 Jun 1;326(6):L687-L697. doi: 10.1152/ajplung.00277.2023. Epub 2024 Apr 2. Am J Physiol Lung Cell Mol Physiol. 2024. PMID: 38563965
Cellular lysates and media supernatant were harvested for assays of cellular signaling, protein expression, and cytokine release. These were repeated with dual silencing of WWOX and zyxin. Control and EC Wwox KO mice were subjected to high tidal volume ventilation. ...EC W …
Cellular lysates and media supernatant were harvested for assays of cellular signaling, protein expression, and cytokine release. These were …